3U12A

The pleckstrin homology (ph) domain of usp37
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
104
structure length
104
Chain Sequence
SLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The pleckstrin homology (PH) domain of USP37
rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords USP37 protein
total genus 22
structure length 104
sequence length 104
chains with identical sequence B
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2011-09-29
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.180 Mainly Beta Roll PH-domain like PH-domain like 3u12A00
3U12A
chains in the Genus database with same CATH superfamily
4HAYB 1WGUA 2K2JA 1PFJA 2D10A 2DN6A 3QBVB 2GS0A 2UVMA 5JLJB 2Z4DA 3U7DA 1N3HA 4TYZA 3TVVA 1DDWA 4GOUA 4F7UP 1FHWA 5DI9B 5C5BB 1ZM0A 2E2XA 2P8VA 1AQCA 1DBHA 2KR0A 4ZRIA 4Z2MB 2XQNM 1DYNA 1RJ2A 2KUPA 2I5CA 2RRFA 3QIJA 3SYXA 1V88A 3O96A 1K5GB 2LOZA 4HAUB 4HHVA 2J0MA 2H7EA 5FI0A 3KSYA 1MIXA 4HB0B 2LG1A 2VRWB 3PVUA 4L1RA 1EGXA 1TQZA 1V5UA 2L1CA 5HE2A 3SNHA 2D9XA 3DXDA 2KCJA 1XD4A 1NTYA 1LB1A 1MK9B 3P6AA 1V5MA 5C16A 4QJ5B 5JHHA 3PZDA 2K8EA 3A8QA 1ZVRA 2CAYA 2Z59A 3ODOA 4KAXB 5I2SA 1FOEA 3NWAA 4DBBA 3PVWA 2OTXA 1W1HA 2Q13A 2YVCA 3MDBC 3TFMA 3DXEA 1NTVA 5KCVA 1BWNA 5LG4B 2Y7BA 1M7EA 3PG7A 3RCPA 1Y19B 1W1GA 1FGYA 4HSIA 5DHFB 1XR0B 1FB8A 2DYNA 4ZRKA 1ZSQA 5J3QA 4GNKB 5D27A 1EF1A 4GN1A 2VKIA 1UNQA 1WGQA 4TKNA 2DHKA 1QC6A 3NWFA 4MT7A 2COAA 5I2MA 2R0DA 1MAIA 5D3WA 1H4RA 2ZPYA 2BCJA 1UPQA 4A6FA 1E5WA 3KY9A 3DXCA 5HE3A 2GCLA 5EFXA 2D9WA 1IRSA 2JP2A 1U2BA 4B6HA 3N7CA 2DHIA 1EVHA 2RNRB 3WYFB 5D3YA 4NSWA 2Z14A 1OY2A 1ZC3B 2CODA 4CHMA 1KZ7A 3HSAA 1GC7A 4NY0A 2N0YA 3P7ZA 1Y5OA 2PZ1A 5JHGA 2COFA 4EKUA 2MFQA 2D9VA 4XWXA 1KZGA 4HB2B 3BJIA 3ZDTA 2P0HA 1WI1A 4KVGB 1P6SA 1V5PA 4YL8A 2GJYA 2Z0QA 3LJUX 2P0FA 2J59M 3KRWA 3CXBB 1MPHA 3FVCA 1FGZA 1XCGA 4MY6A 1XKEA 3U8ZA 3A58A 1OMWA 2L2IA 4C0AA 4Z2NA 1BAKA 1U29A 2DKQA 2IYBA 4YONA 1ZC4B 4HB3B 1M7RA 1U27A 3UZTA 3M1IB 1T77A 3D8FA 2ZKMX 1U5DA 5CLQB 3VIAA 1UEFA 4KHBB 4P7IA 3TO1A 5FI1A 3PSCA 2D2QA 4Y94A 3IVFA 3HIEA 3A8PA 3VOQA 4A6FB 5C79A 4WSFA 1BTNA 2DTCA 2I5FA 5D3XA 2K00A 2Z13A 2ELBA 1Q67A 2DHJA 4D0NB 2DLWA 1UNRA 2EMTA 2NZ8B 2Z0PA 1WG7A 3A98B 5L81A 1I7AA 3QWMA 3DCXA 2G35A 4ZRJA 4HAVB 2CY4A 2Y8GA 1U5EA 2KUQA 1UNPA 3PEGA 1OQNA 3B77A 2Z0OA 4IFSA 2IFSA 1X05A 1EAZA 4OSNA 1H10A 1XODA 2EJ8A 4WJ7A 2ADZA 3FM8C 3HQCA 2HTHB 2YS1A 2DA0A 3V5WA 2DYQA 1ISNA 2P0DA 1KI1B 1J0WA 2YF0A 1TXDA 2NMBA 4F7GA 4KHAA 4PNKA 1QQGA 2AL6A 2W2XD 2YT1A 1MI1A 1DDMA 4GZUA 2N23A 3D8DA 1P3RA 4KHBA 2AEHA 4IAPA 2V76A 2ROZB 2MWNB 3ML4A 2J0JA 1X11A 3NSUA 2GCJA 1PMSA 3SO6A 2DKPA 2LYDA 2M14A 4L6EA 2D9ZA 5KQ1A 2W2XC 1P5TA 2YRYA 2NBVA 3ULBA 1W1DA 4A5KA 3PP2A 1K5DB 2M38A 2H7DA 2EMSA 1FHOA 1MK7B 1FAOA 3MPXA 2K2UA 4EMOA 3ODXA 1XX0A 1LW3A 4QXAB 4GXBA 1BTKA 2KIEA 2I1KA 1SHCA 2D4QA 4GMVA 4BBKA 4DX8A 1WJ1A 2YT2A 3AJ4A 5C6RA 2YS3A 2COCA 3TCAA 1ZYIA 5KQ4A 2LULA 2FJUB 2Y8FA 1UPRA 2OQBA 2UZSA 5DH9B 2HE7A 1DDVA 5IRSA 4HATB 2J0KA 3AU5A 3WA0A 3ZVRA 1FHXA 2D9YA 4GMXB 5LOPB 2RUKB 3PVLA 2CRFA 1GC6A 4CHJA 1AWEA 5CLLB 3HK0A 3G9WA 2YSZA 4MK0A 1SGHA 1B55A 3ODWA 2VSZA 3SV1A 3CIKA 4KHOA 1V89A 1MIZB 2QKMA 3T06A 2ELAA 2RSGA 2GUMA 2YT0A 2R2YA 4HDOA 3OANA 4K17A 2RVBB 3F5RA 4DX90 3D8EA 3HW2B 4HAXB 4DIXA 1U5GA 1MKEA 4QJ4B 4K81A 5JP4A 1X1GA 1TJ6A 1RRPB 4PQ0A 5M4YB 1I2HA 1NI2A 4D6WA 3F0WA 1NU2A 2KIGA 2W2WA 5GOWB 2EC1A 4QJ3B 3OHMB 5C5BA 3SUZA 4IOYX 2KGXB 2ROVA 2YS5A 2K49A 5D3VA 2DX1A 3KZ1A 1WVHA 3GYPA 4GPTB 1PLSA 1V61A 1X86A 2LKOA 5DIFB 3U12A 1Z87A 4CYEA 1J19A 3GYOA 2RGNB 2X18A 3FSSA 3ULCA 4DXAB 2MKRA 3NWDA 3FEHA 3BINA 4HDQA 2I1JA 2R09A 2CY5A 4CSQA 2LOXA 2FJLA 3X23A 5J3YA 5HE1A 3AU4A 3KRXA 3TW1A 2QKLA 1WJMA 4WVFB 1DROA 4K2PA 4HB4B 2MDXA 4A6HA 4HAWB 2DX5A 3NW8A 1X1FA 2D11A 4OT1A 5HE0A 2UZRA 2RLOA 4F7HA 4EJNA 5LONB 2DFKA 1GG3A 5DHAB 4H8SA 4A6KA 4K2OA 5J3TA 1U5FA 4HAZB
chains in the Genus database with same CATH topology
3TW1A 4Z2NA 2RRFA 4HSIA 2GCLA 2Z13A 4QXAB 4KHOA 3NW8A 4PQ0A 5M4YB 3U12A 4D6WA 4QJ5B 2KIEA 2Z4DA 4OT1A 3HIEA 3GYOA 2KIGA 5IRSA 3FSSA 4GNKB 4KHAA 2K8EA 3TVVA 4QJ3B 2GUMA 5LG4B 4GOUA 2R2YA 2Z59A 2NBVA 3OHMB 2KUQA 2ZKMX 3NWDA 5I2SA 2YT2A 2Z14A 3NWFA 3NWAA 4IFSA 4L1RA 4IOYX 4KHBA 4DIXA 4KHBB 5I2MA 4CSQA 1ZYIA 3TO1A 3FVCA 2KR0A 4QJ4B 4OSNA 4Z2MB 2K49A 2FJUB 2GCJA 3GYPA 3A58A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3U12 A; 
#chains in the Genus database with same CATH topology
 4HAY B;  1WGU A;  2K2J A;  1PFJ A;  2D10 A;  2DN6 A;  3QBV B;  2GS0 A;  2UVM A;  5JLJ B;  2Z4D A;  3U7D A;  1N3H A;  4TYZ A;  3TVV A;  1DDW A;  4GOU A;  4F7U P;  1FHW A;  5DI9 B;  5C5B B;  1ZM0 A;  2E2X A;  2P8V A;  1AQC A;  1DBH A;  2KR0 A;  4ZRI A;  4Z2M B;  2XQN M;  1DYN A;  1RJ2 A;  2KUP A;  2I5C A;  2RRF A;  3QIJ A;  3SYX A;  1V88 A;  3O96 A;  1K5G B;  2LOZ A;  4HAU B;  4HHV A;  2J0M A;  2H7E A;  5FI0 A;  3KSY A;  1MIX A;  4HB0 B;  2LG1 A;  2VRW B;  3PVU A;  4L1R A;  1EGX A;  1TQZ A;  1V5U A;  2L1C A;  5HE2 A;  3SNH A;  2D9X A;  3DXD A;  2KCJ A;  1XD4 A;  1NTY A;  1LB1 A;  1MK9 B;  3P6A A;  1V5M A;  5C16 A;  4QJ5 B;  5JHH A;  3PZD A;  2K8E A;  3A8Q A;  1ZVR A;  2CAY A;  2Z59 A;  3ODO A;  4KAX B;  5I2S A;  1FOE A;  3NWA A;  4DBB A;  3PVW A;  2OTX A;  1W1H A;  2Q13 A;  2YVC A;  3MDB C;  3TFM A;  3DXE A;  1NTV A;  5KCV A;  1BWN A;  5LG4 B;  2Y7B A;  1M7E A;  3PG7 A;  3RCP A;  1Y19 B;  1W1G A;  1FGY A;  4HSI A;  5DHF B;  1XR0 B;  1FB8 A;  2DYN A;  4ZRK A;  1ZSQ A;  5J3Q A;  4GNK B;  5D27 A;  1EF1 A;  4GN1 A;  2VKI A;  1UNQ A;  1WGQ A;  4TKN A;  2DHK A;  1QC6 A;  3NWF A;  4MT7 A;  2COA A;  5I2M A;  2R0D A;  1MAI A;  5D3W A;  1H4R A;  2ZPY A;  2BCJ A;  1UPQ A;  4A6F A;  1E5W A;  3KY9 A;  3DXC A;  5HE3 A;  2GCL A;  5EFX A;  2D9W A;  1IRS A;  2JP2 A;  1U2B A;  4B6H A;  3N7C A;  2DHI A;  1EVH A;  2RNR B;  3WYF B;  5D3Y A;  4NSW A;  2Z14 A;  1OY2 A;  1ZC3 B;  2COD A;  4CHM A;  1KZ7 A;  3HSA A;  1GC7 A;  4NY0 A;  2N0Y A;  3P7Z A;  1Y5O A;  2PZ1 A;  5JHG A;  2COF A;  4EKU A;  2MFQ A;  2D9V A;  4XWX A;  1KZG A;  4HB2 B;  3BJI A;  3ZDT A;  2P0H A;  1WI1 A;  4KVG B;  1P6S A;  1V5P A;  4YL8 A;  2GJY A;  2Z0Q A;  3LJU X;  2P0F A;  2J59 M;  3KRW A;  3CXB B;  1MPH A;  3FVC A;  1FGZ A;  1XCG A;  4MY6 A;  1XKE A;  3U8Z A;  3A58 A;  1OMW A;  2L2I A;  4C0A A;  4Z2N A;  1BAK A;  1U29 A;  2DKQ A;  2IYB A;  4YON A;  1ZC4 B;  4HB3 B;  1M7R A;  1U27 A;  3UZT A;  3M1I B;  1T77 A;  3D8F A;  2ZKM X;  1U5D A;  5CLQ B;  3VIA A;  1UEF A;  4KHB B;  4P7I A;  3TO1 A;  5FI1 A;  3PSC A;  2D2Q A;  4Y94 A;  3IVF A;  3HIE A;  3A8P A;  3VOQ A;  4A6F B;  5C79 A;  4WSF A;  1BTN A;  2DTC A;  2I5F A;  5D3X A;  2K00 A;  2Z13 A;  2ELB A;  1Q67 A;  2DHJ A;  4D0N B;  2DLW A;  1UNR A;  2EMT A;  2NZ8 B;  2Z0P A;  1WG7 A;  3A98 B;  5L81 A;  1I7A A;  3QWM A;  3DCX A;  2G35 A;  4ZRJ A;  4HAV B;  2CY4 A;  2Y8G A;  1U5E A;  2KUQ A;  1UNP A;  3PEG A;  1OQN A;  3B77 A;  2Z0O A;  4IFS A;  2IFS A;  1X05 A;  1EAZ A;  4OSN A;  1H10 A;  1XOD A;  2EJ8 A;  4WJ7 A;  2ADZ A;  3FM8 C;  3HQC A;  2HTH B;  2YS1 A;  2DA0 A;  3V5W A;  2DYQ A;  1ISN A;  2P0D A;  1KI1 B;  1J0W A;  2YF0 A;  1TXD A;  2NMB A;  4F7G A;  4KHA A;  4PNK A;  1QQG A;  2AL6 A;  2W2X D;  2YT1 A;  1MI1 A;  1DDM A;  4GZU A;  2N23 A;  3D8D A;  1P3R A;  4KHB A;  2AEH A;  4IAP A;  2V76 A;  2ROZ B;  2MWN B;  3ML4 A;  2J0J A;  1X11 A;  3NSU A;  2GCJ A;  1PMS A;  3SO6 A;  2DKP A;  2LYD A;  2M14 A;  4L6E A;  2D9Z A;  5KQ1 A;  2W2X C;  1P5T A;  2YRY A;  2NBV A;  3ULB A;  1W1D A;  4A5K A;  3PP2 A;  1K5D B;  2M38 A;  2H7D A;  2EMS A;  1FHO A;  1MK7 B;  1FAO A;  3MPX A;  2K2U A;  4EMO A;  3ODX A;  1XX0 A;  1LW3 A;  4QXA B;  4GXB A;  1BTK A;  2KIE A;  2I1K A;  1SHC A;  2D4Q A;  4GMV A;  4BBK A;  4DX8 A;  1WJ1 A;  2YT2 A;  3AJ4 A;  5C6R A;  2YS3 A;  2COC A;  3TCA A;  1ZYI A;  5KQ4 A;  2LUL A;  2FJU B;  2Y8F A;  1UPR A;  2OQB A;  2UZS A;  5DH9 B;  2HE7 A;  1DDV A;  5IRS A;  4HAT B;  2J0K A;  3AU5 A;  3WA0 A;  3ZVR A;  1FHX A;  2D9Y A;  4GMX B;  5LOP B;  2RUK B;  3PVL A;  2CRF A;  1GC6 A;  4CHJ A;  1AWE A;  5CLL B;  3HK0 A;  3G9W A;  2YSZ A;  4MK0 A;  1SGH A;  1B55 A;  3ODW A;  2VSZ A;  3SV1 A;  3CIK A;  4KHO A;  1V89 A;  1MIZ B;  2QKM A;  3T06 A;  2ELA A;  2RSG A;  2GUM A;  2YT0 A;  2R2Y A;  4HDO A;  3OAN A;  4K17 A;  2RVB B;  3F5R A;  4DX9 0;  3D8E A;  3HW2 B;  4HAX B;  4DIX A;  1U5G A;  1MKE A;  4QJ4 B;  4K81 A;  5JP4 A;  1X1G A;  1TJ6 A;  1RRP B;  4PQ0 A;  5M4Y B;  1I2H A;  1NI2 A;  4D6W A;  3F0W A;  1NU2 A;  2KIG A;  2W2W A;  5GOW B;  2EC1 A;  4QJ3 B;  3OHM B;  5C5B A;  3SUZ A;  4IOY X;  2KGX B;  2ROV A;  2YS5 A;  2K49 A;  5D3V A;  2DX1 A;  3KZ1 A;  1WVH A;  3GYP A;  4GPT B;  1PLS A;  1V61 A;  1X86 A;  2LKO A;  5DIF B;  3U12 A;  1Z87 A;  4CYE A;  1J19 A;  3GYO A;  2RGN B;  2X18 A;  3FSS A;  3ULC A;  4DXA B;  2MKR A;  3NWD A;  3FEH A;  3BIN A;  4HDQ A;  2I1J A;  2R09 A;  2CY5 A;  4CSQ A;  2LOX A;  2FJL A;  3X23 A;  5J3Y A;  5HE1 A;  3AU4 A;  3KRX A;  3TW1 A;  2QKL A;  1WJM A;  4WVF B;  1DRO A;  4K2P A;  4HB4 B;  2MDX A;  4A6H A;  4HAW B;  2DX5 A;  3NW8 A;  1X1F A;  2D11 A;  4OT1 A;  5HE0 A;  2UZR A;  2RLO A;  4F7H A;  4EJN A;  5LON B;  2DFK A;  1GG3 A;  5DHA B;  4H8S A;  4A6K A;  4K2O A;  5J3T A;  1U5F A;  4HAZ B; 
#chains in the Genus database with same CATH homology
 3TW1 A;  4Z2N A;  2RRF A;  4HSI A;  2GCL A;  2Z13 A;  4QXA B;  4KHO A;  3NW8 A;  4PQ0 A;  5M4Y B;  3U12 A;  4D6W A;  4QJ5 B;  2KIE A;  2Z4D A;  4OT1 A;  3HIE A;  3GYO A;  2KIG A;  5IRS A;  3FSS A;  4GNK B;  4KHA A;  2K8E A;  3TVV A;  4QJ3 B;  2GUM A;  5LG4 B;  4GOU A;  2R2Y A;  2Z59 A;  2NBV A;  3OHM B;  2KUQ A;  2ZKM X;  3NWD A;  5I2S A;  2YT2 A;  2Z14 A;  3NWF A;  3NWA A;  4IFS A;  4L1R A;  4IOY X;  4KHB A;  4DIX A;  4KHB B;  5I2M A;  4CSQ A;  1ZYI A;  3TO1 A;  3FVC A;  2KR0 A;  4QJ4 B;  4OSN A;  4Z2M B;  2K49 A;  2FJU B;  2GCJ A;  3GYP A;  3A58 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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