1TXD | Genus

Total Genus 127

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	127
sequence length	373
structure length	352
Chain Sequence	PPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNFVNQAVKEAENKQRLEDYQRRLDTSSLVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCTFSPVIKLSTVLVRQVATNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Signaling protein
source organism	Homo sapiens
publication title	Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. pubmed doi rcsb
molecule keywords	Rho guanine nucleotide exchange factor 12
total genus	127
structure length	352
sequence length	373
ec nomenclature
pdb deposition date	2004-07-03

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00621	RhoGEF	RhoGEF domain
A	PF17838	PH_16	PH domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain; Chain A	Dbl homology (DH) domain	1txdA01
2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	1txdA02

2D9ZA 2DN6A 2M38A 3VOQA 4GPTB 3ULCA 1X1GA 2RUKB 1ZC3B 2DYQA 2UZSA 1RJ2A 2DLWA 4GZUA 2P0HA 1KZGA 3FEHA 3ZDTA 1FGZA 3DXCA 5GOWB 2R0DA 4ZRIA 2MDXA 2I1KA 2QKMA 1IRSA 3SYXA 3TW1A 5KQ1A 2J59M 1P3RA 1FGYA 3A8QA 3N7CA 5DI9B 2YS1A 2JP2A 2W2XC 4GOUA 1OMWA 1QC6A 3EO2A 2DFKA 4YL8A 2I5CA 2X18A 3PVWA 3ODXA 3F0WA 3PSCA 2XQNM 4DXAB 4HAUB 4EKUA 3NSUA 3KY9A 2Z0PA 1FAOA 1U5DA 1SHCA 2GCJA 3PVUA 4BBKA 2Y8FA 2KUPA 3O96A 4HB4B 1TJ6A 2EC1A 2YT1A 4DX90 3M1IB 1X1FA 5C79A 4HAZB 3OANA 3QIJA 1U2BA 1WI1A 5JLJB 1UEFA 1W1DA 4KHAA 3ODWA 1J0WA 3GF9A 3F5RA 3D8FA 1UPQA 1DYNA 3KSYA 1BAKA 1XX0A 1U5GA 4D0NB 5D3YA 2D2QA 4TKNA 1V88A 3X23A 2D9YA 1M7RA 1UNQA 2CAYA 3JV3A 4KHBB 1ZM0A 5JHGA 2ELAA 2MFQA 4KVGB 1BTKA 3ODOA 2ROZB 2Y8GA 1EGXA 4K2OA 1P6SA 2VRWB 1DDWA 4HAVB 2H7DA 4EJNA 3U8ZA 1U5EA 3KRXA 4HDQA 2RSGA 2EJ8A 5C5BA 3VIAA 5L81A 1XD4A 2OTXA 5DHFB 2EMSA 4WSFA 5D3XA 4A6KA 2L2IA 5DHAB 1WVHA 1NTYA 3D8EA 4KAXB 5JP4A 2COAA 2PZ1A 3FSSA 1V61A 3ML4A 2KR9A 2LG1A 2FJLA 5HE3A 4F7GA 4D0OA 3GYOA 2P8VA 2Q13A 1Y19B 4B6HA 1WG7A 1XODA 4YONA 3P6AA 2AEHA 1NTVA 1EF1A 3WYFB 1I2HA 4HATB 2HE7A 2YS5A 4WVFB 1WGUA 2ADZA 1Q67A 2VKIA 2BCJA 5LONB 2LKOA 4HB2B 2HTHB 1NI2A 5HE2A 5CLQB 2DHKA 5CLLB 5FI0A 2ROVA 1J19A 3DXDA 5D27A 3A8PA 5C6RA 3T06A 1WGQA 2R09A 1GC7A 4GMVA 2J0MA 1ZSQA 3PG7A 1WJ1A 2MKRA 1RRPB 3SNHA 4GN1A 1MIZB 2GJYA 1ZVRA 2IFSA 2GS0A 1UNPA 2E2XA 2IYBA 3TCAA 1ZC4B 2ELBA 3MPXA 3HQCA 1BY1A 3IVFA 1W1GA 4WJ7A 1MPHA 3WA0A 2DHIA 4DX8A 1WJMA 1QQGA 1OY2A 2D9WA 2DYNA 3U7DA 2W2XD 2AL6A 1FHXA 3KRWA 4A6FB 4K2PA 5EFXA 2KCJA 2KGXB 3PP2A 1GC6A 3PZDA 2G35A 2J0KA 2I1JA 4Z2MB 2OQBA 2LOZA 4KHOA 2I5FA 2D9VA 5D3VA 4CYEA 3ZVRA 3G9WA 3SUZA 3FM8C 4XWXA 1DBHA 2RVBB 3KZ1A 1V5UA 1Z87A 2W2WA 2YF0A 5KQ4A 1EAZA 4MY6A 1X11A 1DDMA 1ISNA 5FI1A 2NMBA 2CODA 1X86A 3ULBA 1KI1B 1AQCA 2LYDA 3A98B 1UPRA 2P0FA 2VSZA 2V76A 3RCPA 1I7AA 2P0DA 2DKQA 1B55A 1FB8A 2H7EA 4A6HA 3MDBC 1K5GB 2YRYA 3TO1A 3CXBB 2YT0A 3DXEA 2RLOA 2YSZA 4A5KA 4A6FA 1W1HA 3HW2B 1XKEA 1FHWA 1AWEA 1P5TA 2COFA 4C0AA 1MK7B 2MWNB 4MK0A 2D11A 2UVMA 4K81A 4DBBA 1KZ7A 3V5WA 3AU5A 2DA0A 2DX5A 3TFMA 2LULA 1DROA 1DDVA 1E5WA 1UNRA 1BTNA 4ZRJA 3CIKA 3AJ4A 3TVVA 3UZTA 4Z2NA 5LOPB 2M14A 5JHHA 1FHOA 5HE0A 3D8DA 3QBVB 3QWMA 3PVLA 4K17A 2GCLA 2D4QA 4HDOA 2COCA 4HB0B 1PFJA 2K00A 1V5MA 5D3WA 4HAXB 1BWNA 1MK9B 2J0JA 2Z0QA 4GMXB 2NZ8B 2N0YA 3HK0A 1OQNA 2Y7BA 5J3TA 1TXDA 2EMTA 1NU2A 4HHVA 4P7IA 4IAPA 4HAWB 1GG3A 4IFSA 2CRFA 2DKPA 5J3QA 4H8SA 4Y94A 2QKLA 1TQZA 4GYVA 5C5BB 1N3HA 2L1CA 4TYZA 2DTCA 4L6EA 3SV1A 2LOXA 4HAYB 4IOYX 1K5DB 1Y5OA 1XR0B 1SGHA 5DIFB 1V5PA 4GXBA 1X05A 2CY5A 1F5XA 1LB1A 4CHJA 2ZPYA 4HB3B 1H10A 2D9XA 3BINA 4F7HA 4ZRKA 4CHMA 1MKEA 2YS3A 2Z0OA 5KCVA 2YVCA 4PQ0A 2DX1A 3SO6A 4F7UP 2CY4A 1FOEA 1EVHA 3PEGA 5HE1A 2DHJA 3AU4A 3P7ZA 1PMSA 4EMOA 5C16A 4PNKA 3GYPA 4NY0A 2UZRA 1U27A 1LW3A 1H4RA 5DH9B 2RGNB 1MIXA 2RNRB 4NSWA 3BJIA 1U5FA 2D10A 1PLSA 1U29A 1V89A 2N23A 2K2UA 1M7EA 1XCGA 2K2JA 3LJUX 1MAIA 5J3YA 4MT7A
chains in the Genus database with same CATH superfamily

2D9ZA 2DN6A 2M38A 3VOQA 4GPTB 3ULCA 1X1GA 2RUKB 1ZC3B 2DYQA 2UZSA 1RJ2A 2DLWA 4GZUA 2P0HA 1KZGA 3FEHA 3ZDTA 1FGZA 3DXCA 5GOWB 3NW8A 2R0DA 4ZRIA 2MDXA 2I1KA 2QKMA 1IRSA 4QJ3B 3SYXA 3TW1A 5KQ1A 2J59M 1P3RA 1FGYA 2KIEA 3A8QA 3N7CA 5DI9B 2YS1A 2JP2A 2W2XC 3NWAA 3DCXA 4GOUA 1OMWA 1QC6A 3EO2A 2DFKA 4YL8A 2I5CA 2X18A 3PVWA 3ODXA 3F0WA 2KR0A 3PSCA 2XQNM 4DXAB 4HAUB 4EKUA 3NSUA 3KY9A 4GNKB 2Z0PA 1FAOA 1U5DA 1SHCA 2GCJA 4L1RA 2Z4DA 2K8EA 3PVUA 4BBKA 2Z13A 2Y8FA 2KUPA 3O96A 4HB4B 1TJ6A 2EC1A 2YT1A 4DX90 3M1IB 1X1FA 5C79A 4HAZB 3OANA 3QIJA 1U2BA 1WI1A 5JLJB 1UEFA 1W1DA 4KHAA 3ODWA 3B77A 1J0WA 3GF9A 3F5RA 3D8FA 1UPQA 1DYNA 3KSYA 1BAKA 1XX0A 1U5GA 4D0NB 5D3YA 2D2QA 4TKNA 1V88A 3X23A 2D9YA 1M7RA 1UNQA 2CAYA 3JV3A 4KHBB 1ZM0A 5JHGA 2ELAA 2MFQA 4KVGB 1BTKA 3ODOA 2ROZB 2Y8GA 1EGXA 5I2MA 4K2OA 1P6SA 2VRWB 1MI1A 1DDWA 4HAVB 2H7DA 4EJNA 3U8ZA 1U5EA 3KRXA 4HDQA 2RSGA 2EJ8A 5C5BA 3VIAA 5L81A 2ZKMX 1XD4A 2OTXA 5DHFB 1ZYIA 2EMSA 4WSFA 5D3XA 4A6KA 2L2IA 5I2SA 5DHAB 1WVHA 1NTYA 3D8EA 4KAXB 5JP4A 2COAA 2PZ1A 3FSSA 1V61A 3OHMB 3ML4A 2KR9A 2LG1A 2FJLA 5HE3A 4F7GA 4D0OA 3GYOA 2P8VA 2Q13A 1Y19B 4B6HA 1WG7A 1XODA 4YONA 3P6AA 2AEHA 1NTVA 1EF1A 3WYFB 1I2HA 4HATB 2HE7A 2YS5A 4WVFB 1WGUA 2ADZA 1Q67A 2VKIA 4KHBA 2BCJA 5LONB 4CSQA 2LKOA 4HB2B 2HTHB 1NI2A 5HE2A 5CLQB 2DHKA 5CLLB 5FI0A 2ROVA 1J19A 3DXDA 5D27A 2KIGA 3A8PA 5C6RA 3T06A 1WGQA 5LG4B 2R09A 1GC7A 4GMVA 2J0MA 1ZSQA 3PG7A 2RRFA 1WJ1A 2MKRA 1RRPB 3SNHA 4GN1A 1MIZB 2GJYA 1ZVRA 2IFSA 2GS0A 1UNPA 2E2XA 2GUMA 2IYBA 3TCAA 2YT2A 1ZC4B 2ELBA 3MPXA 3HQCA 3FVCA 1BY1A 3IVFA 1W1GA 4WJ7A 1MPHA 3HIEA 3WA0A 2DHIA 4DX8A 1WJMA 1QQGA 1OY2A 2D9WA 2DYNA 3U7DA 2W2XD 2R2YA 2AL6A 1FHXA 3KRWA 4A6FB 4K2PA 3HSAA 5EFXA 2KCJA 2KGXB 3PP2A 1GC6A 3PZDA 2G35A 2J0KA 2I1JA 4Z2MB 2OQBA 2LOZA 4KHOA 2I5FA 2D9VA 5D3VA 4CYEA 2Z14A 3ZVRA 3G9WA 3SUZA 3FM8C 4QJ5B 4XWXA 1DBHA 2RVBB 4QXAB 3KZ1A 1V5UA 1Z87A 2W2WA 2YF0A 5KQ4A 1EAZA 4MY6A 1X11A 1DDMA 1ISNA 5FI1A 2NMBA 2CODA 1X86A 4OT1A 3ULBA 4D6WA 1KI1B 4QJ4B 1AQCA 2LYDA 3A98B 1UPRA 2P0FA 2VSZA 2V76A 3RCPA 1I7AA 5IRSA 2P0DA 2DKQA 1B55A 1FB8A 2H7EA 4A6HA 3MDBC 1K5GB 2YRYA 3TO1A 3CXBB 3NWDA 2YT0A 3DXEA 4DIXA 2RLOA 2YSZA 4A5KA 4A6FA 1W1HA 3HW2B 1XKEA 1FHWA 1AWEA 1P5TA 2COFA 4C0AA 1MK7B 3NWFA 2MWNB 4MK0A 2D11A 2UVMA 4K81A 4DBBA 1KZ7A 3V5WA 3AU5A 2DA0A 2DX5A 3TFMA 2LULA 1DROA 1DDVA 1E5WA 1UNRA 1BTNA 4ZRJA 3CIKA 3AJ4A 3TVVA 3UZTA 4Z2NA 5M4YB 5LOPB 2M14A 5JHHA 1FHOA 5HE0A 3D8DA 3QBVB 3QWMA 3PVLA 4K17A 2GCLA 2D4QA 4HDOA 2COCA 2KUQA 4HB0B 1PFJA 2K00A 1V5MA 5D3WA 4HAXB 1BWNA 1MK9B 2J0JA 2Z0QA 4GMXB 2NZ8B 2N0YA 3HK0A 1OQNA 2Y7BA 5J3TA 1TXDA 2EMTA 1NU2A 4HHVA 4P7IA 4IAPA 4HAWB 1GG3A 4IFSA 2CRFA 3U12A 2DKPA 1T77A 5J3QA 4H8SA 4HSIA 4Y94A 2QKLA 1TQZA 4GYVA 5C5BB 1N3HA 2L1CA 4TYZA 2DTCA 4L6EA 3SV1A 2LOXA 4HAYB 4IOYX 1K5DB 1Y5OA 1XR0B 1SGHA 5DIFB 1V5PA 3A58A 4GXBA 1X05A 2CY5A 1F5XA 1LB1A 4CHJA 2ZPYA 4HB3B 1H10A 2D9XA 3BINA 4F7HA 4ZRKA 4CHMA 1MKEA 2YS3A 2Z0OA 5KCVA 2YVCA 4PQ0A 2DX1A 3SO6A 4F7UP 2FJUB 2CY4A 1FOEA 1EVHA 3PEGA 5HE1A 2DHJA 3AU4A 2NBVA 1PMSA 3P7ZA 4EMOA 5C16A 4PNKA 3GYPA 4NY0A 2UZRA 1U27A 1LW3A 1H4RA 5DH9B 2RGNB 2Z59A 1MIXA 2RNRB 4NSWA 3BJIA 1U5FA 2D10A 4OSNA 1PLSA 1U29A 1V89A 2N23A 2K2UA 1M7EA 1XCGA 2K2JA 3LJUX 1MAIA 2K49A 5J3YA 4MT7A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2D9Z A;  2DN6 A;  2M38 A;  3VOQ A;  4GPT B;  3ULC A;  1X1G A;  2RUK B;  1ZC3 B;  2DYQ A;  2UZS A;  1RJ2 A;  2DLW A;  4GZU A;  2P0H A;  1KZG A;  3FEH A;  3ZDT A;  1FGZ A;  3DXC A;  5GOW B;  2R0D A;  4ZRI A;  2MDX A;  2I1K A;  2QKM A;  1IRS A;  3SYX A;  3TW1 A;  5KQ1 A;  2J59 M;  1P3R A;  1FGY A;  3A8Q A;  3N7C A;  5DI9 B;  2YS1 A;  2JP2 A;  2W2X C;  4GOU A;  1OMW A;  1QC6 A;  3EO2 A;  2DFK A;  4YL8 A;  2I5C A;  2X18 A;  3PVW A;  3ODX A;  3F0W A;  3PSC A;  2XQN M;  4DXA B;  4HAU B;  4EKU A;  3NSU A;  3KY9 A;  2Z0P A;  1FAO A;  1U5D A;  1SHC A;  2GCJ A;  3PVU A;  4BBK A;  2Y8F A;  2KUP A;  3O96 A;  4HB4 B;  1TJ6 A;  2EC1 A;  2YT1 A;  4DX9 0;  3M1I B;  1X1F A;  5C79 A;  4HAZ B;  3OAN A;  3QIJ A;  1U2B A;  1WI1 A;  5JLJ B;  1UEF A;  1W1D A;  4KHA A;  3ODW A;  1J0W A;  3GF9 A;  3F5R A;  3D8F A;  1UPQ A;  1DYN A;  3KSY A;  1BAK A;  1XX0 A;  1U5G A;  4D0N B;  5D3Y A;  2D2Q A;  4TKN A;  1V88 A;  3X23 A;  2D9Y A;  1M7R A;  1UNQ A;  2CAY A;  3JV3 A;  4KHB B;  1ZM0 A;  5JHG A;  2ELA A;  2MFQ A;  4KVG B;  1BTK A;  3ODO A;  2ROZ B;  2Y8G A;  1EGX A;  4K2O A;  1P6S A;  2VRW B;  1DDW A;  4HAV B;  2H7D A;  4EJN A;  3U8Z A;  1U5E A;  3KRX A;  4HDQ A;  2RSG A;  2EJ8 A;  5C5B A;  3VIA A;  5L81 A;  1XD4 A;  2OTX A;  5DHF B;  2EMS A;  4WSF A;  5D3X A;  4A6K A;  2L2I A;  5DHA B;  1WVH A;  1NTY A;  3D8E A;  4KAX B;  5JP4 A;  2COA A;  2PZ1 A;  3FSS A;  1V61 A;  3ML4 A;  2KR9 A;  2LG1 A;  2FJL A;  5HE3 A;  4F7G A;  4D0O A;  3GYO A;  2P8V A;  2Q13 A;  1Y19 B;  4B6H A;  1WG7 A;  1XOD A;  4YON A;  3P6A A;  2AEH A;  1NTV A;  1EF1 A;  3WYF B;  1I2H A;  4HAT B;  2HE7 A;  2YS5 A;  4WVF B;  1WGU A;  2ADZ A;  1Q67 A;  2VKI A;  2BCJ A;  5LON B;  2LKO A;  4HB2 B;  2HTH B;  1NI2 A;  5HE2 A;  5CLQ B;  2DHK A;  5CLL B;  5FI0 A;  2ROV A;  1J19 A;  3DXD A;  5D27 A;  3A8P A;  5C6R A;  3T06 A;  1WGQ A;  2R09 A;  1GC7 A;  4GMV A;  2J0M A;  1ZSQ A;  3PG7 A;  1WJ1 A;  2MKR A;  1RRP B;  3SNH A;  4GN1 A;  1MIZ B;  2GJY A;  1ZVR A;  2IFS A;  2GS0 A;  1UNP A;  2E2X A;  2IYB A;  3TCA A;  1ZC4 B;  2ELB A;  3MPX A;  3HQC A;  1BY1 A;  3IVF A;  1W1G A;  4WJ7 A;  1MPH A;  3WA0 A;  2DHI A;  4DX8 A;  1WJM A;  1QQG A;  1OY2 A;  2D9W A;  2DYN A;  3U7D A;  2W2X D;  2AL6 A;  1FHX A;  3KRW A;  4A6F B;  4K2P A;  5EFX A;  2KCJ A;  2KGX B;  3PP2 A;  1GC6 A;  3PZD A;  2G35 A;  2J0K A;  2I1J A;  4Z2M B;  2OQB A;  2LOZ A;  4KHO A;  2I5F A;  2D9V A;  5D3V A;  4CYE A;  3ZVR A;  3G9W A;  3SUZ A;  3FM8 C;  4XWX A;  1DBH A;  2RVB B;  3KZ1 A;  1V5U A;  1Z87 A;  2W2W A;  2YF0 A;  5KQ4 A;  1EAZ A;  4MY6 A;  1X11 A;  1DDM A;  1ISN A;  5FI1 A;  2NMB A;  2COD A;  1X86 A;  3ULB A;  1KI1 B;  1AQC A;  2LYD A;  3A98 B;  1UPR A;  2P0F A;  2VSZ A;  2V76 A;  3RCP A;  1I7A A;  2P0D A;  2DKQ A;  1B55 A;  1FB8 A;  2H7E A;  4A6H A;  3MDB C;  1K5G B;  2YRY A;  3TO1 A;  3CXB B;  2YT0 A;  3DXE A;  2RLO A;  2YSZ A;  4A5K A;  4A6F A;  1W1H A;  3HW2 B;  1XKE A;  1FHW A;  1AWE A;  1P5T A;  2COF A;  4C0A A;  1MK7 B;  2MWN B;  4MK0 A;  2D11 A;  2UVM A;  4K81 A;  4DBB A;  1KZ7 A;  3V5W A;  3AU5 A;  2DA0 A;  2DX5 A;  3TFM A;  2LUL A;  1DRO A;  1DDV A;  1E5W A;  1UNR A;  1BTN A;  4ZRJ A;  3CIK A;  3AJ4 A;  3TVV A;  3UZT A;  4Z2N A;  5LOP B;  2M14 A;  5JHH A;  1FHO A;  5HE0 A;  3D8D A;  3QBV B;  3QWM A;  3PVL A;  4K17 A;  2GCL A;  2D4Q A;  4HDO A;  2COC A;  4HB0 B;  1PFJ A;  2K00 A;  1V5M A;  5D3W A;  4HAX B;  1BWN A;  1MK9 B;  2J0J A;  2Z0Q A;  4GMX B;  2NZ8 B;  2N0Y A;  3HK0 A;  1OQN A;  2Y7B A;  5J3T A;  1TXD A;  2EMT A;  1NU2 A;  4HHV A;  4P7I A;  4IAP A;  4HAW B;  1GG3 A;  4IFS A;  2CRF A;  2DKP A;  5J3Q A;  4H8S A;  4Y94 A;  2QKL A;  1TQZ A;  4GYV A;  5C5B B;  1N3H A;  2L1C A;  4TYZ A;  2DTC A;  4L6E A;  3SV1 A;  2LOX A;  4HAY B;  4IOY X;  1K5D B;  1Y5O A;  1XR0 B;  1SGH A;  5DIF B;  1V5P A;  4GXB A;  1X05 A;  2CY5 A;  1F5X A;  1LB1 A;  4CHJ A;  2ZPY A;  4HB3 B;  1H10 A;  2D9X A;  3BIN A;  4F7H A;  4ZRK A;  4CHM A;  1MKE A;  2YS3 A;  2Z0O A;  5KCV A;  2YVC A;  4PQ0 A;  2DX1 A;  3SO6 A;  4F7U P;  2CY4 A;  1FOE A;  1EVH A;  3PEG A;  5HE1 A;  2DHJ A;  3AU4 A;  3P7Z A;  1PMS A;  4EMO A;  5C16 A;  4PNK A;  3GYP A;  4NY0 A;  2UZR A;  1U27 A;  1LW3 A;  1H4R A;  5DH9 B;  2RGN B;  1MIX A;  2RNR B;  4NSW A;  3BJI A;  1U5F A;  2D10 A;  1PLS A;  1U29 A;  1V89 A;  2N23 A;  2K2U A;  1M7E A;  1XCG A;  2K2J A;  3LJU X;  1MAI A;  5J3Y A;  4MT7 A; 
#chains in the Genus database with same CATH topology
 2D9Z A;  2DN6 A;  2M38 A;  3VOQ A;  4GPT B;  3ULC A;  1X1G A;  2RUK B;  1ZC3 B;  2DYQ A;  2UZS A;  1RJ2 A;  2DLW A;  4GZU A;  2P0H A;  1KZG A;  3FEH A;  3ZDT A;  1FGZ A;  3DXC A;  5GOW B;  3NW8 A;  2R0D A;  4ZRI A;  2MDX A;  2I1K A;  2QKM A;  1IRS A;  4QJ3 B;  3SYX A;  3TW1 A;  5KQ1 A;  2J59 M;  1P3R A;  1FGY A;  2KIE A;  3A8Q A;  3N7C A;  5DI9 B;  2YS1 A;  2JP2 A;  2W2X C;  3NWA A;  3DCX A;  4GOU A;  1OMW A;  1QC6 A;  3EO2 A;  2DFK A;  4YL8 A;  2I5C A;  2X18 A;  3PVW A;  3ODX A;  3F0W A;  2KR0 A;  3PSC A;  2XQN M;  4DXA B;  4HAU B;  4EKU A;  3NSU A;  3KY9 A;  4GNK B;  2Z0P A;  1FAO A;  1U5D A;  1SHC A;  2GCJ A;  4L1R A;  2Z4D A;  2K8E A;  3PVU A;  4BBK A;  2Z13 A;  2Y8F A;  2KUP A;  3O96 A;  4HB4 B;  1TJ6 A;  2EC1 A;  2YT1 A;  4DX9 0;  3M1I B;  1X1F A;  5C79 A;  4HAZ B;  3OAN A;  3QIJ A;  1U2B A;  1WI1 A;  5JLJ B;  1UEF A;  1W1D A;  4KHA A;  3ODW A;  3B77 A;  1J0W A;  3GF9 A;  3F5R A;  3D8F A;  1UPQ A;  1DYN A;  3KSY A;  1BAK A;  1XX0 A;  1U5G A;  4D0N B;  5D3Y A;  2D2Q A;  4TKN A;  1V88 A;  3X23 A;  2D9Y A;  1M7R A;  1UNQ A;  2CAY A;  3JV3 A;  4KHB B;  1ZM0 A;  5JHG A;  2ELA A;  2MFQ A;  4KVG B;  1BTK A;  3ODO A;  2ROZ B;  2Y8G A;  1EGX A;  5I2M A;  4K2O A;  1P6S A;  2VRW B;  1MI1 A;  1DDW A;  4HAV B;  2H7D A;  4EJN A;  3U8Z A;  1U5E A;  3KRX A;  4HDQ A;  2RSG A;  2EJ8 A;  5C5B A;  3VIA A;  5L81 A;  2ZKM X;  1XD4 A;  2OTX A;  5DHF B;  1ZYI A;  2EMS A;  4WSF A;  5D3X A;  4A6K A;  2L2I A;  5I2S A;  5DHA B;  1WVH A;  1NTY A;  3D8E A;  4KAX B;  5JP4 A;  2COA A;  2PZ1 A;  3FSS A;  1V61 A;  3OHM B;  3ML4 A;  2KR9 A;  2LG1 A;  2FJL A;  5HE3 A;  4F7G A;  4D0O A;  3GYO A;  2P8V A;  2Q13 A;  1Y19 B;  4B6H A;  1WG7 A;  1XOD A;  4YON A;  3P6A A;  2AEH A;  1NTV A;  1EF1 A;  3WYF B;  1I2H A;  4HAT B;  2HE7 A;  2YS5 A;  4WVF B;  1WGU A;  2ADZ A;  1Q67 A;  2VKI A;  4KHB A;  2BCJ A;  5LON B;  4CSQ A;  2LKO A;  4HB2 B;  2HTH B;  1NI2 A;  5HE2 A;  5CLQ B;  2DHK A;  5CLL B;  5FI0 A;  2ROV A;  1J19 A;  3DXD A;  5D27 A;  2KIG A;  3A8P A;  5C6R A;  3T06 A;  1WGQ A;  5LG4 B;  2R09 A;  1GC7 A;  4GMV A;  2J0M A;  1ZSQ A;  3PG7 A;  2RRF A;  1WJ1 A;  2MKR A;  1RRP B;  3SNH A;  4GN1 A;  1MIZ B;  2GJY A;  1ZVR A;  2IFS A;  2GS0 A;  1UNP A;  2E2X A;  2GUM A;  2IYB A;  3TCA A;  2YT2 A;  1ZC4 B;  2ELB A;  3MPX A;  3HQC A;  3FVC A;  1BY1 A;  3IVF A;  1W1G A;  4WJ7 A;  1MPH A;  3HIE A;  3WA0 A;  2DHI A;  4DX8 A;  1WJM A;  1QQG A;  1OY2 A;  2D9W A;  2DYN A;  3U7D A;  2W2X D;  2R2Y A;  2AL6 A;  1FHX A;  3KRW A;  4A6F B;  4K2P A;  3HSA A;  5EFX A;  2KCJ A;  2KGX B;  3PP2 A;  1GC6 A;  3PZD A;  2G35 A;  2J0K A;  2I1J A;  4Z2M B;  2OQB A;  2LOZ A;  4KHO A;  2I5F A;  2D9V A;  5D3V A;  4CYE A;  2Z14 A;  3ZVR A;  3G9W A;  3SUZ A;  3FM8 C;  4QJ5 B;  4XWX A;  1DBH A;  2RVB B;  4QXA B;  3KZ1 A;  1V5U A;  1Z87 A;  2W2W A;  2YF0 A;  5KQ4 A;  1EAZ A;  4MY6 A;  1X11 A;  1DDM A;  1ISN A;  5FI1 A;  2NMB A;  2COD A;  1X86 A;  4OT1 A;  3ULB A;  4D6W A;  1KI1 B;  4QJ4 B;  1AQC A;  2LYD A;  3A98 B;  1UPR A;  2P0F A;  2VSZ A;  2V76 A;  3RCP A;  1I7A A;  5IRS A;  2P0D A;  2DKQ A;  1B55 A;  1FB8 A;  2H7E A;  4A6H A;  3MDB C;  1K5G B;  2YRY A;  3TO1 A;  3CXB B;  3NWD A;  2YT0 A;  3DXE A;  4DIX A;  2RLO A;  2YSZ A;  4A5K A;  4A6F A;  1W1H A;  3HW2 B;  1XKE A;  1FHW A;  1AWE A;  1P5T A;  2COF A;  4C0A A;  1MK7 B;  3NWF A;  2MWN B;  4MK0 A;  2D11 A;  2UVM A;  4K81 A;  4DBB A;  1KZ7 A;  3V5W A;  3AU5 A;  2DA0 A;  2DX5 A;  3TFM A;  2LUL A;  1DRO A;  1DDV A;  1E5W A;  1UNR A;  1BTN A;  4ZRJ A;  3CIK A;  3AJ4 A;  3TVV A;  3UZT A;  4Z2N A;  5M4Y B;  5LOP B;  2M14 A;  5JHH A;  1FHO A;  5HE0 A;  3D8D A;  3QBV B;  3QWM A;  3PVL A;  4K17 A;  2GCL A;  2D4Q A;  4HDO A;  2COC A;  2KUQ A;  4HB0 B;  1PFJ A;  2K00 A;  1V5M A;  5D3W A;  4HAX B;  1BWN A;  1MK9 B;  2J0J A;  2Z0Q A;  4GMX B;  2NZ8 B;  2N0Y A;  3HK0 A;  1OQN A;  2Y7B A;  5J3T A;  1TXD A;  2EMT A;  1NU2 A;  4HHV A;  4P7I A;  4IAP A;  4HAW B;  1GG3 A;  4IFS A;  2CRF A;  3U12 A;  2DKP A;  1T77 A;  5J3Q A;  4H8S A;  4HSI A;  4Y94 A;  2QKL A;  1TQZ A;  4GYV A;  5C5B B;  1N3H A;  2L1C A;  4TYZ A;  2DTC A;  4L6E A;  3SV1 A;  2LOX A;  4HAY B;  4IOY X;  1K5D B;  1Y5O A;  1XR0 B;  1SGH A;  5DIF B;  1V5P A;  3A58 A;  4GXB A;  1X05 A;  2CY5 A;  1F5X A;  1LB1 A;  4CHJ A;  2ZPY A;  4HB3 B;  1H10 A;  2D9X A;  3BIN A;  4F7H A;  4ZRK A;  4CHM A;  1MKE A;  2YS3 A;  2Z0O A;  5KCV A;  2YVC A;  4PQ0 A;  2DX1 A;  3SO6 A;  4F7U P;  2FJU B;  2CY4 A;  1FOE A;  1EVH A;  3PEG A;  5HE1 A;  2DHJ A;  3AU4 A;  2NBV A;  1PMS A;  3P7Z A;  4EMO A;  5C16 A;  4PNK A;  3GYP A;  4NY0 A;  2UZR A;  1U27 A;  1LW3 A;  1H4R A;  5DH9 B;  2RGN B;  2Z59 A;  1MIX A;  2RNR B;  4NSW A;  3BJI A;  1U5F A;  2D10 A;  4OSN A;  1PLS A;  1U29 A;  1V89 A;  2N23 A;  2K2U A;  1M7E A;  1XCG A;  2K2J A;  3LJU X;  1MAI A;  2K49 A;  5J3Y A;  4MT7 A; 
#chains in the Genus database with same CATH homology
 2D9Z A;  2DN6 A;  2M38 A;  3VOQ A;  4GPT B;  3ULC A;  1X1G A;  2RUK B;  1ZC3 B;  2DYQ A;  2UZS A;  1RJ2 A;  2DLW A;  4GZU A;  2P0H A;  1KZG A;  3FEH A;  3ZDT A;  1FGZ A;  3DXC A;  5GOW B;  2R0D A;  4ZRI A;  2MDX A;  2I1K A;  2QKM A;  1IRS A;  3SYX A;  3TW1 A;  5KQ1 A;  2J59 M;  1P3R A;  1FGY A;  3A8Q A;  3N7C A;  5DI9 B;  2YS1 A;  2JP2 A;  2W2X C;  4GOU A;  1OMW A;  1QC6 A;  3EO2 A;  2DFK A;  4YL8 A;  2I5C A;  2X18 A;  3PVW A;  3ODX A;  3F0W A;  3PSC A;  2XQN M;  4DXA B;  4HAU B;  4EKU A;  3NSU A;  3KY9 A;  2Z0P A;  1FAO A;  1U5D A;  1SHC A;  2GCJ A;  3PVU A;  4BBK A;  2Y8F A;  2KUP A;  3O96 A;  4HB4 B;  1TJ6 A;  2EC1 A;  2YT1 A;  4DX9 0;  3M1I B;  1X1F A;  5C79 A;  4HAZ B;  3OAN A;  3QIJ A;  1U2B A;  1WI1 A;  5JLJ B;  1UEF A;  1W1D A;  4KHA A;  3ODW A;  1J0W A;  3GF9 A;  3F5R A;  3D8F A;  1UPQ A;  1DYN A;  3KSY A;  1BAK A;  1XX0 A;  1U5G A;  4D0N B;  5D3Y A;  2D2Q A;  4TKN A;  1V88 A;  3X23 A;  2D9Y A;  1M7R A;  1UNQ A;  2CAY A;  3JV3 A;  4KHB B;  1ZM0 A;  5JHG A;  2ELA A;  2MFQ A;  4KVG B;  1BTK A;  3ODO A;  2ROZ B;  2Y8G A;  1EGX A;  4K2O A;  1P6S A;  2VRW B;  1DDW A;  4HAV B;  2H7D A;  4EJN A;  3U8Z A;  1U5E A;  3KRX A;  4HDQ A;  2RSG A;  2EJ8 A;  5C5B A;  3VIA A;  5L81 A;  1XD4 A;  2OTX A;  5DHF B;  2EMS A;  4WSF A;  5D3X A;  4A6K A;  2L2I A;  5DHA B;  1WVH A;  1NTY A;  3D8E A;  4KAX B;  5JP4 A;  2COA A;  2PZ1 A;  3FSS A;  1V61 A;  3ML4 A;  2KR9 A;  2LG1 A;  2FJL A;  5HE3 A;  4F7G A;  4D0O A;  3GYO A;  2P8V A;  2Q13 A;  1Y19 B;  4B6H A;  1WG7 A;  1XOD A;  4YON A;  3P6A A;  2AEH A;  1NTV A;  1EF1 A;  3WYF B;  1I2H A;  4HAT B;  2HE7 A;  2YS5 A;  4WVF B;  1WGU A;  2ADZ A;  1Q67 A;  2VKI A;  2BCJ A;  5LON B;  2LKO A;  4HB2 B;  2HTH B;  1NI2 A;  5HE2 A;  5CLQ B;  2DHK A;  5CLL B;  5FI0 A;  2ROV A;  1J19 A;  3DXD A;  5D27 A;  3A8P A;  5C6R A;  3T06 A;  1WGQ A;  2R09 A;  1GC7 A;  4GMV A;  2J0M A;  1ZSQ A;  3PG7 A;  1WJ1 A;  2MKR A;  1RRP B;  3SNH A;  4GN1 A;  1MIZ B;  2GJY A;  1ZVR A;  2IFS A;  2GS0 A;  1UNP A;  2E2X A;  2IYB A;  3TCA A;  1ZC4 B;  2ELB A;  3MPX A;  3HQC A;  1BY1 A;  3IVF A;  1W1G A;  4WJ7 A;  1MPH A;  3WA0 A;  2DHI A;  4DX8 A;  1WJM A;  1QQG A;  1OY2 A;  2D9W A;  2DYN A;  3U7D A;  2W2X D;  2AL6 A;  1FHX A;  3KRW A;  4A6F B;  4K2P A;  5EFX A;  2KCJ A;  2KGX B;  3PP2 A;  1GC6 A;  3PZD A;  2G35 A;  2J0K A;  2I1J A;  4Z2M B;  2OQB A;  2LOZ A;  4KHO A;  2I5F A;  2D9V A;  5D3V A;  4CYE A;  3ZVR A;  3G9W A;  3SUZ A;  3FM8 C;  4XWX A;  1DBH A;  2RVB B;  3KZ1 A;  1V5U A;  1Z87 A;  2W2W A;  2YF0 A;  5KQ4 A;  1EAZ A;  4MY6 A;  1X11 A;  1DDM A;  1ISN A;  5FI1 A;  2NMB A;  2COD A;  1X86 A;  3ULB A;  1KI1 B;  1AQC A;  2LYD A;  3A98 B;  1UPR A;  2P0F A;  2VSZ A;  2V76 A;  3RCP A;  1I7A A;  2P0D A;  2DKQ A;  1B55 A;  1FB8 A;  2H7E A;  4A6H A;  3MDB C;  1K5G B;  2YRY A;  3TO1 A;  3CXB B;  2YT0 A;  3DXE A;  2RLO A;  2YSZ A;  4A5K A;  4A6F A;  1W1H A;  3HW2 B;  1XKE A;  1FHW A;  1AWE A;  1P5T A;  2COF A;  4C0A A;  1MK7 B;  2MWN B;  4MK0 A;  2D11 A;  2UVM A;  4K81 A;  4DBB A;  1KZ7 A;  3V5W A;  3AU5 A;  2DA0 A;  2DX5 A;  3TFM A;  2LUL A;  1DRO A;  1DDV A;  1E5W A;  1UNR A;  1BTN A;  4ZRJ A;  3CIK A;  3AJ4 A;  3TVV A;  3UZT A;  4Z2N A;  5LOP B;  2M14 A;  5JHH A;  1FHO A;  5HE0 A;  3D8D A;  3QBV B;  3QWM A;  3PVL A;  4K17 A;  2GCL A;  2D4Q A;  4HDO A;  2COC A;  4HB0 B;  1PFJ A;  2K00 A;  1V5M A;  5D3W A;  4HAX B;  1BWN A;  1MK9 B;  2J0J A;  2Z0Q A;  4GMX B;  2NZ8 B;  2N0Y A;  3HK0 A;  1OQN A;  2Y7B A;  5J3T A;  1TXD A;  2EMT A;  1NU2 A;  4HHV A;  4P7I A;  4IAP A;  4HAW B;  1GG3 A;  4IFS A;  2CRF A;  2DKP A;  5J3Q A;  4H8S A;  4Y94 A;  2QKL A;  1TQZ A;  4GYV A;  5C5B B;  1N3H A;  2L1C A;  4TYZ A;  2DTC A;  4L6E A;  3SV1 A;  2LOX A;  4HAY B;  4IOY X;  1K5D B;  1Y5O A;  1XR0 B;  1SGH A;  5DIF B;  1V5P A;  4GXB A;  1X05 A;  2CY5 A;  1F5X A;  1LB1 A;  4CHJ A;  2ZPY A;  4HB3 B;  1H10 A;  2D9X A;  3BIN A;  4F7H A;  4ZRK A;  4CHM A;  1MKE A;  2YS3 A;  2Z0O A;  5KCV A;  2YVC A;  4PQ0 A;  2DX1 A;  3SO6 A;  4F7U P;  2CY4 A;  1FOE A;  1EVH A;  3PEG A;  5HE1 A;  2DHJ A;  3AU4 A;  3P7Z A;  1PMS A;  4EMO A;  5C16 A;  4PNK A;  3GYP A;  4NY0 A;  2UZR A;  1U27 A;  1LW3 A;  1H4R A;  5DH9 B;  2RGN B;  1MIX A;  2RNR B;  4NSW A;  3BJI A;  1U5F A;  2D10 A;  1PLS A;  1U29 A;  1V89 A;  2N23 A;  2K2U A;  1M7E A;  1XCG A;  2K2J A;  3LJU X;  1MAI A;  5J3Y A;  4MT7 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1TXDA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations