4HSIA

Glycoprotein b from herpes simplex virus type 1, a504p/r505g/q507g/n511g mutant, low-ph
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
619
structure length
601
Chain Sequence
KAENTDANFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINAKGVCRSTAKYVRNNLETTAFHRDDHETDMELKPANAATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATAPTTRNLLTTPKFTVAWDWVPKRPSVCTMTKWQEVDEMLRSEYGGSFRFSSDAISTTFTTNLTEYPLSRVDLGDCIGKDARDAMDRIFARRYNATHIKVGQPQYYLANGGFLIAYQPLLSNTLAELYVREHLREQSVERIKTTSSIEFPGLGFTYGHIQRHVNDMLGRVAIAWCELQNHELTLWNEARKLNPNAIASVTVGRRVSARMLGDVMAVSTCVPVAADNVIVQNSMRISSRPGACYSRPLVSFRYEDQGPLVEGQLGENNELRLTRDAIEPCTVGHRRYFTFGGGYVYFEEYAYSHQLSRADITTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Viral protein
source organism Human herpesvirus 1
publication title Extensive Mutagenesis of the HSV-1 gB Ectodomain Reveals Remarkable Stability of Its Postfusion Form.
pubmed doi rcsb
molecule keywords Envelope glycoprotein B
total genus 128
structure length 601
sequence length 619
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00606 Glycoprotein_B Herpesvirus Glycoprotein B ectodomain
A PF17416 Glycoprot_B_PH1 Herpesvirus Glycoprotein B
A PF17417 Glycoprot_B_PH2 Herpesvirus Glycoprotein B PH-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.29.100 Mainly Beta Roll PH-domain like PH-domain like 4hsiA03
3.30.1450.20 Alpha Beta 2-Layer Sandwich Beta-lactamase Inhibitory Protein; Chain:B, domain 1 Beta-lactamase Inhibitory Protein; Chain:B, domain 1 4hsiA01
4OSNA 3FVCA 3NWFA 3NW8A 3NWDA 3NWAA 4OT1A 4HSIA 2GUMA 4L1RA
chains in the Genus database with same CATH superfamily
2GCJA 3NWFA 1U27A 3P6AA 1MPHA 3ML4A 1ISNA 2K49A 2YT1A 3F0WA 2MDXA 5HE3A 2D9ZA 1MKEA 5J3YA 1Z87A 5C6RA 5DIFB 5I2MA 2KIGA 2GUMA 3GMUB 4IFSA 3MPXA 2ADZA 5HE2A 1BTNA 1QQGA 4KVGB 3D8DA 3FSSA 5L81A 1N3HA 1U5EA 3P7ZA 1X1FA 1DROA 5FI0A 3E2KC 2YVCA 4GXBA 4KHBA 3TO1A 1FHXA 1OY2A 2LG1A 3ULCA 2YS3A 4GNKB 1X05A 3MDBC 2EMTA 4HHVA 4K2OA 3C7UB 1WJ1A 1UEFA 2Y7BA 3N4IB 2PXGA 3SO6A 3QIJA 1OQNA 1GG3A 3T06A 4A6HA 2Z0QA 1X86A 3HSAA 4Z2NA 2YS5A 2CAYA 4HDQA 3AU5A 1GC7A 4DX90 4QXAB 1TJ6A 1U5FA 3LJUX 3HIEA 4DX8A 4K81A 3CXBB 3SNHA 2ROZB 1W1HA 4HAUB 3FVCA 1BWNA 1TQZA 4KAXB 2E2XA 2I1KA 2I1JA 1EF1A 3PP2A 4CHMA 2G2WB 1SHCA 2GCLA 1FHWA 2QKLA 3D8EA 4GPTB 3TW1A 4XWXA 2IYBA 1E5WA 1P6SA 2EC1A 2MKRA 3FM8C 1H10A 2K8EA 3SUZA 3KZ1A 4KHAA 2DKPA 2RSGA 2ELAA 3PVUA 3DXDA 4EKUA 3PVWA 2Y8GA 3HW2B 1U29A 4ZRKA 2YS1A 5GOWB 4A5KA 2RNRB 4F7HA 2Z0PA 1B55A 2CY4A 5DHFB 4Z2MB 2DA0A 2KUPA 1DBHA 1K5GB 1FOEA 1T77A 4MY6A 2KIEA 4HDOA 1PFJA 1UNQA 1TXDA 3PVLA 2ROVA 3PSCA 2DHIA 2DLWA 1WGUA 1V5UA 1EGXA 4OT1A 2D9WA 4D6WA 2YT2A 1XXMC 1NTYA 1W1DA 2BCJA 2NBVA 2PZ1A 2J59M 4ZRIA 1WG7A 2FJLA 2P0DA 5AYWE 4DXAB 4C0AA 2DN6A 1M7RA 4L6EA 2ZPYA 1ZC3B 2KCJA 2KGXB 2DKQA 2RRFA 2P0HA 2AL6A 2DTCA 4KHBB 3GYOA 4HB2B 4EJNA 1RRPB 1IRSA 3GYPA 3ZVRA 3FEHA 5D0QE 4MK0A 2COFA 1MAIA 4KHOA 2AEHA 1P5TA 2MWNB 5KQ1A 2ZKMX 5LONB 1FGZA 2MFQA 3U8ZA 3KY9A 3NW8A 4PNKA 4QJ5B 4BBKA 2OQBA 1W1GA 1U5DA 2HTHB 5C5BA 1Q67A 3ODOA 3U12A 4GMXB 2OTXA 2D2QA 4K17A 2VSZA 2I5CA 4WVFB 5KQ4A 3A8PA 3KSYA 4WJ7A 3DXEA 2LOXA 2P8VA 1XCGA 2NZ8B 3A8QA 1U2BA 1AQCA 2D10A 1Y19B 2COAA 2YF0A 4HAXB 1P3RA 3F5RA 1J19A 1MK7B 2IFSA 1ZC4B 4HAYB 3UZTA 1GC6A 4DIXA 4YONA 4K2PA 4P7IA 5D3YA 4A6FA 2L1CA 3KRWA 2COCA 4HAZB 5DHAB 4TKNA 2W2XD 1OMWA 5I2SA 1MK9B 3ODWA 4DBBA 4QJ3B 1EAZA 2HE7A 1PLSA 2L2IA 5HE0A 3BINA 3WA0A 5D3VA 2DX5A 4NY0A 2ELBA 1I2HA 2LOZA 3OANA 3D4EA 3TVVA 3IVFA 3M1IB 3AJ4A 1XODA 1FAOA 3DXCA 3NWDA 2KXXA 2DX1A 3ZDTA 2K2JA 5DI9B 1BAKA 1V89A 2R09A 5FI1A 4OSNA 1KZGA 3B77A 3AU4A 1WI1A 3HK0A 3OHMB 5CLQB 1KI1B 1X1GA 5LG4B 1MIXA 4HB4B 2YH9A 2QKMA 4DM5A 2CRFA 3NWAA 1QC6A 2D9YA 3ODXA 4GN1A 2XQNM 5DH9B 2CODA 2UVMA 2KM7A 1MI1A 3VIAA 1PMSA 1FB8A 4TYZA 2P0FA 3PEGA 3WYFB 2YT0A 1UNRA 5C5BB 5EFXA 5D3WA 2D11A 1WJMA 2DYNA 2G2UB 2KR0A 3HQCA 5D27A 2Z14A 2KUQA 4HB0B 1FHOA 3N7CA 5D0OE 4YL8A 3BJIA 1Y5OA 3X23A 1V5PA 5CLLB 3ULBA 1EVHA 2NMBA 4CYEA 4HB3B 5JHHA 5KCVA 2UZSA 3D8FA 2VRWB 5C16A 4F7GA 2B5RC 3C7VB 3RCPA 4A6FB 4A6KA 1DDWA 1NU2A 3PG7A 2LKOA 2RGNB 2LYDA 5HE1A 3TCAA 3U7DA 2RVBB 3O96A 4ZRJA 3G9WA 2Y8FA 4H8SA 5JLJB 1U5GA 2DFKA 4GMVA 5IRSA 1XKEA 4MT7A 1H4RA 2LULA 2YSZA 1AWEA 1M7EA 2W2XC 1V88A 4HATB 5JP4A 2FJUB 1WVHA 1FGYA 2K2UA 3E2LC 5J3QA 3KRXA 5JHGA 3DCXA 1J0WA 2RUKB 2J0KA 1KZ7A 2RLOA 4QJ4B 1ZSQA 2Z0OA 4IOYX 2DYQA 1X11A 1JTGB 2V76A 2D4QA 3A58A 1SGHA 1I7AA 4WSFA 2R0DA 3PZDA 4F7UP 5LOPB 4IAPA 4HSIA 3CIKA 2J0MA 2H7DA 2Z13A 1NTVA 1K5DB 4Y94A 2EMSA 2Q13A 2G35A 2GJYA 2K00A 2GS0A 3QBVB 4GOUA 1NI2A 4L1RA 3NSUA 1ZVRA 2H7EA 2I5FA 2D9XA 1V5MA 1UPQA 2JP2A 1DYNA 3TFMA 1XX0A 4B6HA 2DHJA 1S0WC 3SV1A 5M4YB 1ZYIA 4HAVB 2EJ8A 2VKIA 5EKQE 1MIZB 5D3XA 1LW3A 4D0NB 1XD4A 1XR0B 4CSQA 1DDVA 2R2YA 2D9VA 1UNPA 2N23A 2M38A 2N0YA 4PQ0A 2YRYA 1RJ2A 5J3TA 3C4OB 1UPRA 2J0JA 3VOQA 4GZUA 1V61A 2CY5A 3QWMA 5C79A 3SYXA 1ZM0A 3A98B 1BTKA 1LB1A 4HAWB 4CHJA 1DDMA 2DHKA 3V5WA 2Z59A 4NSWA 2M14A 2X18A 3C4PB 1WGQA 2Z4DA 2W2WA 4EMOA 2UZRA
chains in the Genus database with same CATH topology
2GCJA 3NWFA 5I2SA 4Z2MB 4QJ3B 5IRSA 2K49A 2KIEA 4OT1A 4D6WA 2YT2A 5I2MA 2KIGA 1XXMC 3D4EA 2GUMA 3TVVA 2NBVA 3GMUB 2FJUB 4IFSA 2KXXA 3NWDA 5AYWE 3E2LC 3FSSA 4OSNA 4QJ4B 2RRFA 4IOYX 3OHMB 4KHBB 5LG4B 3E2KC 3GYOA 1JTGB 2YH9A 4DM5A 4KHBA 3NWAA 3TO1A 3A58A 3GYPA 5D0QE 4GNKB 4KHOA 4HSIA 2KM7A 3C7UB 2ZKMX 3N4IB 2PXGA 2Z13A 3NW8A 4QJ5B 4Z2NA 4GOUA 4L1RA 2G2UB 2KR0A 2Z14A 2KUQA 4QXAB 3U12A 5D0OE 1S0WC 3HIEA 5M4YB 1ZYIA 5EKQE 4CSQA 3FVCA 2R2YA 4PQ0A 3C4OB 2G2WB 2GCLA 3TW1A 2B5RC 3C7VB 4DIXA 2K8EA 2Z59A 4KHAA 3C4PB 2Z4DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OSN A;  3FVC A;  3NWF A;  3NW8 A;  3NWD A;  3NWA A;  4OT1 A;  4HSI A;  2GUM A;  4L1R A; 
#chains in the Genus database with same CATH topology
 2GCJ A;  3NWF A;  1U27 A;  3P6A A;  1MPH A;  3ML4 A;  1ISN A;  2K49 A;  2YT1 A;  3F0W A;  2MDX A;  5HE3 A;  2D9Z A;  1MKE A;  5J3Y A;  1Z87 A;  5C6R A;  5DIF B;  5I2M A;  2KIG A;  2GUM A;  3GMU B;  4IFS A;  3MPX A;  2ADZ A;  5HE2 A;  1BTN A;  1QQG A;  4KVG B;  3D8D A;  3FSS A;  5L81 A;  1N3H A;  1U5E A;  3P7Z A;  1X1F A;  1DRO A;  5FI0 A;  3E2K C;  2YVC A;  4GXB A;  4KHB A;  3TO1 A;  1FHX A;  1OY2 A;  2LG1 A;  3ULC A;  2YS3 A;  4GNK B;  1X05 A;  3MDB C;  2EMT A;  4HHV A;  4K2O A;  3C7U B;  1WJ1 A;  1UEF A;  2Y7B A;  3N4I B;  2PXG A;  3SO6 A;  3QIJ A;  1OQN A;  1GG3 A;  3T06 A;  4A6H A;  2Z0Q A;  1X86 A;  3HSA A;  4Z2N A;  2YS5 A;  2CAY A;  4HDQ A;  3AU5 A;  1GC7 A;  4DX9 0;  4QXA B;  1TJ6 A;  1U5F A;  3LJU X;  3HIE A;  4DX8 A;  4K81 A;  3CXB B;  3SNH A;  2ROZ B;  1W1H A;  4HAU B;  3FVC A;  1BWN A;  1TQZ A;  4KAX B;  2E2X A;  2I1K A;  2I1J A;  1EF1 A;  3PP2 A;  4CHM A;  2G2W B;  1SHC A;  2GCL A;  1FHW A;  2QKL A;  3D8E A;  4GPT B;  3TW1 A;  4XWX A;  2IYB A;  1E5W A;  1P6S A;  2EC1 A;  2MKR A;  3FM8 C;  1H10 A;  2K8E A;  3SUZ A;  3KZ1 A;  4KHA A;  2DKP A;  2RSG A;  2ELA A;  3PVU A;  3DXD A;  4EKU A;  3PVW A;  2Y8G A;  3HW2 B;  1U29 A;  4ZRK A;  2YS1 A;  5GOW B;  4A5K A;  2RNR B;  4F7H A;  2Z0P A;  1B55 A;  2CY4 A;  5DHF B;  4Z2M B;  2DA0 A;  2KUP A;  1DBH A;  1K5G B;  1FOE A;  1T77 A;  4MY6 A;  2KIE A;  4HDO A;  1PFJ A;  1UNQ A;  1TXD A;  3PVL A;  2ROV A;  3PSC A;  2DHI A;  2DLW A;  1WGU A;  1V5U A;  1EGX A;  4OT1 A;  2D9W A;  4D6W A;  2YT2 A;  1XXM C;  1NTY A;  1W1D A;  2BCJ A;  2NBV A;  2PZ1 A;  2J59 M;  4ZRI A;  1WG7 A;  2FJL A;  2P0D A;  5AYW E;  4DXA B;  4C0A A;  2DN6 A;  1M7R A;  4L6E A;  2ZPY A;  1ZC3 B;  2KCJ A;  2KGX B;  2DKQ A;  2RRF A;  2P0H A;  2AL6 A;  2DTC A;  4KHB B;  3GYO A;  4HB2 B;  4EJN A;  1RRP B;  1IRS A;  3GYP A;  3ZVR A;  3FEH A;  5D0Q E;  4MK0 A;  2COF A;  1MAI A;  4KHO A;  2AEH A;  1P5T A;  2MWN B;  5KQ1 A;  2ZKM X;  5LON B;  1FGZ A;  2MFQ A;  3U8Z A;  3KY9 A;  3NW8 A;  4PNK A;  4QJ5 B;  4BBK A;  2OQB A;  1W1G A;  1U5D A;  2HTH B;  5C5B A;  1Q67 A;  3ODO A;  3U12 A;  4GMX B;  2OTX A;  2D2Q A;  4K17 A;  2VSZ A;  2I5C A;  4WVF B;  5KQ4 A;  3A8P A;  3KSY A;  4WJ7 A;  3DXE A;  2LOX A;  2P8V A;  1XCG A;  2NZ8 B;  3A8Q A;  1U2B A;  1AQC A;  2D10 A;  1Y19 B;  2COA A;  2YF0 A;  4HAX B;  1P3R A;  3F5R A;  1J19 A;  1MK7 B;  2IFS A;  1ZC4 B;  4HAY B;  3UZT A;  1GC6 A;  4DIX A;  4YON A;  4K2P A;  4P7I A;  5D3Y A;  4A6F A;  2L1C A;  3KRW A;  2COC A;  4HAZ B;  5DHA B;  4TKN A;  2W2X D;  1OMW A;  5I2S A;  1MK9 B;  3ODW A;  4DBB A;  4QJ3 B;  1EAZ A;  2HE7 A;  1PLS A;  2L2I A;  5HE0 A;  3BIN A;  3WA0 A;  5D3V A;  2DX5 A;  4NY0 A;  2ELB A;  1I2H A;  2LOZ A;  3OAN A;  3D4E A;  3TVV A;  3IVF A;  3M1I B;  3AJ4 A;  1XOD A;  1FAO A;  3DXC A;  3NWD A;  2KXX A;  2DX1 A;  3ZDT A;  2K2J A;  5DI9 B;  1BAK A;  1V89 A;  2R09 A;  5FI1 A;  4OSN A;  1KZG A;  3B77 A;  3AU4 A;  1WI1 A;  3HK0 A;  3OHM B;  5CLQ B;  1KI1 B;  1X1G A;  5LG4 B;  1MIX A;  4HB4 B;  2YH9 A;  2QKM A;  4DM5 A;  2CRF A;  3NWA A;  1QC6 A;  2D9Y A;  3ODX A;  4GN1 A;  2XQN M;  5DH9 B;  2COD A;  2UVM A;  2KM7 A;  1MI1 A;  3VIA A;  1PMS A;  1FB8 A;  4TYZ A;  2P0F A;  3PEG A;  3WYF B;  2YT0 A;  1UNR A;  5C5B B;  5EFX A;  5D3W A;  2D11 A;  1WJM A;  2DYN A;  2G2U B;  2KR0 A;  3HQC A;  5D27 A;  2Z14 A;  2KUQ A;  4HB0 B;  1FHO A;  3N7C A;  5D0O E;  4YL8 A;  3BJI A;  1Y5O A;  3X23 A;  1V5P A;  5CLL B;  3ULB A;  1EVH A;  2NMB A;  4CYE A;  4HB3 B;  5JHH A;  5KCV A;  2UZS A;  3D8F A;  2VRW B;  5C16 A;  4F7G A;  2B5R C;  3C7V B;  3RCP A;  4A6F B;  4A6K A;  1DDW A;  1NU2 A;  3PG7 A;  2LKO A;  2RGN B;  2LYD A;  5HE1 A;  3TCA A;  3U7D A;  2RVB B;  3O96 A;  4ZRJ A;  3G9W A;  2Y8F A;  4H8S A;  5JLJ B;  1U5G A;  2DFK A;  4GMV A;  5IRS A;  1XKE A;  4MT7 A;  1H4R A;  2LUL A;  2YSZ A;  1AWE A;  1M7E A;  2W2X C;  1V88 A;  4HAT B;  5JP4 A;  2FJU B;  1WVH A;  1FGY A;  2K2U A;  3E2L C;  5J3Q A;  3KRX A;  5JHG A;  3DCX A;  1J0W A;  2RUK B;  2J0K A;  1KZ7 A;  2RLO A;  4QJ4 B;  1ZSQ A;  2Z0O A;  4IOY X;  2DYQ A;  1X11 A;  1JTG B;  2V76 A;  2D4Q A;  3A58 A;  1SGH A;  1I7A A;  4WSF A;  2R0D A;  3PZD A;  4F7U P;  5LOP B;  4IAP A;  4HSI A;  3CIK A;  2J0M A;  2H7D A;  2Z13 A;  1NTV A;  1K5D B;  4Y94 A;  2EMS A;  2Q13 A;  2G35 A;  2GJY A;  2K00 A;  2GS0 A;  3QBV B;  4GOU A;  1NI2 A;  4L1R A;  3NSU A;  1ZVR A;  2H7E A;  2I5F A;  2D9X A;  1V5M A;  1UPQ A;  2JP2 A;  1DYN A;  3TFM A;  1XX0 A;  4B6H A;  2DHJ A;  1S0W C;  3SV1 A;  5M4Y B;  1ZYI A;  4HAV B;  2EJ8 A;  2VKI A;  5EKQ E;  1MIZ B;  5D3X A;  1LW3 A;  4D0N B;  1XD4 A;  1XR0 B;  4CSQ A;  1DDV A;  2R2Y A;  2D9V A;  1UNP A;  2N23 A;  2M38 A;  2N0Y A;  4PQ0 A;  2YRY A;  1RJ2 A;  5J3T A;  3C4O B;  1UPR A;  2J0J A;  3VOQ A;  4GZU A;  1V61 A;  2CY5 A;  3QWM A;  5C79 A;  3SYX A;  1ZM0 A;  3A98 B;  1BTK A;  1LB1 A;  4HAW B;  4CHJ A;  1DDM A;  2DHK A;  3V5W A;  2Z59 A;  4NSW A;  2M14 A;  2X18 A;  3C4P B;  1WGQ A;  2Z4D A;  2W2W A;  4EMO A;  2UZR A; 
#chains in the Genus database with same CATH homology
 2GCJ A;  3NWF A;  5I2S A;  4Z2M B;  4QJ3 B;  5IRS A;  2K49 A;  2KIE A;  4OT1 A;  4D6W A;  2YT2 A;  5I2M A;  2KIG A;  1XXM C;  3D4E A;  2GUM A;  3TVV A;  2NBV A;  3GMU B;  2FJU B;  4IFS A;  2KXX A;  3NWD A;  5AYW E;  3E2L C;  3FSS A;  4OSN A;  4QJ4 B;  2RRF A;  4IOY X;  3OHM B;  4KHB B;  5LG4 B;  3E2K C;  3GYO A;  1JTG B;  2YH9 A;  4DM5 A;  4KHB A;  3NWA A;  3TO1 A;  3A58 A;  3GYP A;  5D0Q E;  4GNK B;  4KHO A;  4HSI A;  2KM7 A;  3C7U B;  2ZKM X;  3N4I B;  2PXG A;  2Z13 A;  3NW8 A;  4QJ5 B;  4Z2N A;  4GOU A;  4L1R A;  2G2U B;  2KR0 A;  2Z14 A;  2KUQ A;  4QXA B;  3U12 A;  5D0O E;  1S0W C;  3HIE A;  5M4Y B;  1ZYI A;  5EKQ E;  4CSQ A;  3FVC A;  2R2Y A;  4PQ0 A;  3C4O B;  2G2W B;  2GCL A;  3TW1 A;  2B5R C;  3C7V B;  4DIX A;  2K8E A;  2Z59 A;  4KHA A;  3C4P B;  2Z4D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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