The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
73
|
sequence length |
260
|
structure length |
241
|
Chain Sequence |
DAEKTLNHLISGFETFEKKINYRFKNKAYLLQAFTHASYHYNTITDYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVKFQLEKNEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLK
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage.
pubmed doi rcsb |
| molecule keywords |
Endoribonuclease Dicer
|
| molecule tags |
Hydrolase
|
| source organism |
Mus musculus
|
| total genus |
73
|
| structure length |
241
|
| sequence length |
260
|
| ec nomenclature |
ec
3.1.26.3: Ribonuclease III. |
| pdb deposition date | 2008-01-30 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00636 | Ribonuclease_3 | Ribonuclease III domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Ribonuclease iii, N-terminal Endonuclease Domain; Chain A | Ribonuclease III domain | ||
| Alpha Beta | 2-Layer Sandwich | Double Stranded RNA Binding Domain | Double Stranded RNA Binding Domain |
#chains in the Genus database with same CATH superfamily 4X66 E; 2L3C A; 4DV6 E; 3LLH A; 2MDR A; 5LMN E; 2GSL A; 2UXD E; 1IBM E; 2RS7 A; 1X47 A; 1T4N A; 2N3H A; 2DMY A; 4NXN E; 2LTR A; 1X49 A; 2FFL A; 4OOG C; 2LBS B; 2UXC E; 1YZ9 A; 3C4B A; 2LTS A; 1IBL E; 2CPN A; 4LF4 E; 2B3T B; 4X8W A; 3T1H E; 4X62 E; 4DR6 E; 1WHQ A; 4DV1 E; 1T4O A; 1WHN A; 2B7V A; 2VQF E; 2UU9 E; 1DI2 A; 2DIX A; 2HHH E; 2RS6 A; 1XMO E; 4M2Z A; 4K0K E; 1JFZ A; 4YY3 E; 4DV2 E; 2UUB E; 4LFB E; 4LF9 E; 4KHP E; 5CFF E; 2EB1 A; 1ZBT A; 3N3W A; 4GKJ E; 2ZM6 E; 1N34 E; 3ADL A; 1HNX E; 2E5L E; 1FKA E; 1RC5 A; 1HR0 E; 2QVW A; 4WYQ B; 4DV7 E; 1EKZ A; 1T4L B; 1YYO A; 2JY9 A; 2N3G A; 1U61 A; 4B3S E; 4DV3 E; 1X48 A; 4DR2 E; 1GQE A; 4LF7 E; 3ADI A; 3HTX A; 4YHH E; 4NXM E; 4JI1 E; 3RV1 A; 2VQE E; 1J5E E; 4DR1 E; 1RQ0 A; 4DR4 E; 3C4T A; 4M30 A; 4DR5 E; 4JI8 E; 2L3J A; 2KHX A; 4DR3 E; 5IWA E; 4OX9 E; 4X64 E; 3ADG A; 4JI5 E; 4JV5 E; 4JI7 E; 1UIL A; 4DV0 E; 1I4S A; 2NUG A; 3VYY A; 4LFC E; 3VYX A; 4AQY E; 2L2N A; 4DUZ E; 2UUC E; 2L2M A; 2UUA E; 4B3T E; 1FJG E; 2JVA A; 4JYA E; 1HNW E; 4DKK A; 2F4V E; 2RTX A; 3O2R B; 3RV0 A; 1XMQ E; 4JI3 E; 1YYK A; 4LF6 E; 3J7Y p; 5LMU E; 2DB2 A; 1IBK E; 1RC7 A; 1O0W A; 2YT4 A; 1XNQ E; 1J26 A; 4JI6 E; 4DR7 E; 1YYW A; 2NA2 A; 5BR8 E; 2LRS A; 4WFT A; 4DUY E; 4DV5 E; 3T1Y E; 1I94 E; 4JI2 E; 1N32 E; 1N33 E; 2EZ6 A; 1N36 E; 1PKP A; 4JI4 E; 2LJH A; 2NUE A; 2UXB E; 2NUF A; 4LFA E; 2A11 A; 2L2K B; 1HNZ E; 3ADJ A; 3O2R A; 4X65 E; 2LUP B; 4LF5 E; 2IHR 1; 3P1X A; 1XNR E; 2LUQ A; 4GKK E; 2L33 A; 1UHZ A; 2RSM A; 4OUN A; 1STU A; 4B3M E; 4DV4 E; 2B7T A; 4B3R E; 3OTO E; 4LF8 E; 1QU6 A; 4JI0 E; #chains in the Genus database with same CATH topology 2LMZ A; 4F54 A; 2YTP A; 2J7J A; 4DV6 E; 1PJQ A; 4RHB B; 4BCA A; 2E72 A; 2YPN A; 2CT1 A; 4WXD A; 1A1H A; 1X47 A; 2N3H A; 2LCE A; 4WSG A; 2EPO A; 2ELZ A; 3QG5 C; 2FFL A; 2YWQ A; 4OOG C; 2YRK A; 3JTZ A; 2EM2 A; 2LBS B; 2HGH A; 2UXC E; 1YZ9 A; 1IBL E; 2R1F A; 2B3T B; 1ZTD A; 3T1H E; 4DV1 E; 4O5G A; 4GEQ B; 1T4O A; 3EQ1 A; 2EOZ A; 2HHH E; 1GZ6 A; 1XMO E; 1NEI A; 2EMH A; 1JFZ A; 4DV2 E; 2YSP A; 1X6F A; 4LFB E; 2EB1 A; 1NCS A; 3RMP A; 4ZYD A; 1HR0 E; 2EMX A; 2B9D A; 4WYQ B; 4R2R A; 2L8T A; 1T4L B; 4M9V C; 4O4K A; 4BHB A; 2EN8 A; 4J8Z A; 1DGC A; 4DR2 E; 2EM7 A; 3MHS C; 4HEI A; 4YHH E; 1YPN A; 3RV1 A; 2EPU A; 2JWO A; 2VQE E; 2R76 A; 1RQ0 A; 4DR1 E; 3C4T A; 2EMC A; 2E1M A; 5AE2 A; 2L3J A; 2KHX A; 4TUI A; 4NHR A; 2EMZ A; 4O43 A; 3L00 A; 5AC5 A; 4GZN C; 1UIL A; 2EOI A; 2V85 A; 1A1G A; 3VYY A; 2YTD A; 2L2N A; 4ZYE A; 2EPP A; 4DUZ E; 4B3T E; 2JVA A; 2V87 A; 3JAM C; 1AH5 A; 2L92 A; 3O2R B; 3RV0 A; 2ODR D; 3C6M A; 1XMQ E; 5IXM B; 2RQL A; 2YTE A; 4R2Q A; 1EH7 A; 4R2P A; 2EPZ A; 2BB8 A; 2LRS A; 4F6N A; 3F6G A; 2V89 A; 2EZ6 A; 1ZU1 A; 3HQ1 A; 1L4S A; 3TQM A; 2M1S A; 3H09 A; 1TF3 A; 2HJJ A; 4NZV A; 4TUG A; 5AAS A; 2A11 A; 1HNZ E; 3ADJ A; 2MKN A; 1JK1 A; 2EOM A; 2GLI A; 2EN3 A; 2EM6 A; 3C6K A; 2L6M A; 5AC4 A; 2EM4 A; 1EH6 A; 2RSM A; 2WCC 3; 2CSH A; 2VRD A; 3DF6 A; 2JXP A; 2EOO A; 4X66 E; 2LV2 A; 2EN7 A; 2L3C A; 2MC5 A; 1N3G A; 2EMY A; 2YU8 A; 3MHH C; 1WXR A; 1QNT A; 1WRJ A; 5LMN E; 2YTJ A; 4F6M A; 2UXD E; 1IBM E; 3FIG A; 5F3W A; 4WX9 A; 2V86 A; 1TF6 A; 2KON A; 1IQS A; 4IS1 C; 2DMY A; 3J81 C; 2KOU A; 4NXN E; 2M4I A; 1A1L A; 3AUZ A; 5DNY A; 2LTS A; 2CPN A; 3J80 C; 3BGH A; 2F8B A; 2JPA A; 3HPS A; 4DR6 E; 1YUJ A; 3KZZ A; 2YRH A; 1WHN A; 2VQF E; 1A1K A; 1T38 A; 2RS6 A; 2ENA A; 2LVH A; 3JU0 A; 4HTG A; 4K0K E; 5A6B D; 2MC6 A; 1UN6 B; 1WJP A; 2DSY A; 2JP9 A; 1PJT A; 2EOJ A; 2EOY A; 3N3W A; 2EPK X; 2EL6 A; 3VHT B; 3ADL A; 2N8X A; 1IMU A; 4FK5 C; 1YYO A; 4M0V A; 2EMW A; 1ZR9 A; 1A1I A; 5KL6 A; 4R03 A; 5A6A A; 4LF7 E; 1A1J A; 4JI1 E; 1J5E E; 3AV0 A; 5ADZ A; 4I8O A; 4JI8 E; 1KJK A; 4X64 E; 4JV5 E; 4DV0 E; 1I4S A; 4LFC E; 4RH8 A; 4P78 A; 2L2M A; 4BC9 A; 2YZT A; 3IWB A; 2EN4 A; 2EN2 A; 1IBK E; 4X9J A; 5KL3 A; 2ENC A; 4DMI A; 2FV4 B; 2LO3 A; 2EE8 A; 4WFT A; 5KL4 A; 2EOF A; 1N36 E; 1PKP A; 1G2D C; 4ZYH A; 3DJW A; 2L2K B; 3THO B; 1GTK A; 4F9C B; 4BMJ A; 1BBO A; 1XNR E; 2EMI A; 4R2E A; 2L33 A; 2MDG A; 3VK6 A; 4DV4 E; 2B7T A; 5A6K A; 3HPZ A; 3OTO E; 4BBY A; 2FGG A; 2EQ1 A; 2EPC A; 2A25 A; 1AAY A; 5A2Q C; 2EQ3 A; 5TSE A; 2EQ0 A; 3KWR A; 5KL2 A; 2EP3 A; 3HXL A; 2LTR A; 1EH8 A; 4WXC A; 2YSO A; 3EPK A; 3BBG A; 1B69 A; 3OML A; 1MEY C; 4LF4 E; 2EML A; 2ENH A; 1X5W A; 1DI2 A; 2B7V A; 2DIX A; 4KZS A; 5LLQ A; 2Q8U A; 2EN1 A; 2EOR A; 4N4R B; 3IWC A; 4IJD A; 3THN A; 5KL5 A; 2JOB A; 2V83 A; 4LU9 A; 4YY3 E; 4LF9 E; 1PDA A; 2EM5 A; 5AE1 A; 1N34 E; 2I9I A; 4F9A B; 1HNX E; 4P7D A; 1RC5 A; 1DQ3 A; 2EJ4 A; 1YUI A; 2I13 A; 2EPM X; 2N3G A; 1X6H A; 2DMI A; 2EPN A; 5A6J A; 2EMA A; 2LJU A; 1GQE A; 3ADI A; 4NXM E; 2YTG A; 5LL6 R; 2EPR A; 4DR4 E; 4L8N A; 4DR5 E; 2ADR A; 2VE7 C; 4DR3 E; 5IWA E; 4OX9 E; 4JI5 E; 4JI7 E; 4Q28 A; 2H36 X; 2NUG A; 3VYX A; 4R2D A; 2UUC E; 1FJG E; 2EPL X; 1KYQ A; 2RTX A; 2EM8 A; 3KZY A; 4F2J C; 2V88 A; 2MKD A; 4WPY A; 3J7Y p; 3UK3 C; 5LMU E; 2DB2 A; 1LLM C; 2WZO A; 1G2F C; 1RC7 A; 1O0W A; 2EMB A; 5AE3 A; 2YT4 A; 1J26 A; 4JI6 E; 4DR7 E; 1YYW A; 5BR8 E; 1I94 E; 1SR9 A; 4DV5 E; 4JI2 E; 1N32 E; 2RPC A; 4JI4 E; 2V8Q B; 3MSW A; 1BB8 A; 2EMF A; 4ZYG A; 2EM9 A; 5IT9 C; 2K4V A; 1YSA C; 2D9H A; 2LT7 A; 2EN6 A; 1PJS A; 4LF5 E; 1X3C A; 2IHR 1; 3P1X A; 1ZAA C; 4GKK E; 4OUN A; 4B3M E; 4B3R E; 3EPJ A; 3ECR A; 4L5N C; 3LLH A; 2EWL A; 2DLK A; 2NAB A; 2MDR A; 2GSL A; 2YRM A; 2EMG A; 2EPA A; 3M99 B; 2RS7 A; 2YTO A; 1T4N A; 2VF1 A; 2YTQ A; 5A69 A; 1X49 A; 3ZOQ B; 4O24 A; 3C4B A; 3BID A; 1BBG A; 2BBG A; 4MLQ A; 2YTF A; 4X8W A; 4X62 E; 4JI0 E; 3BF2 A; 1WHQ A; 1MGT A; 4WSP A; 2UU9 E; 4R2C A; 4F9B B; 2JOX A; 3LML A; 2YTI A; 2PRT A; 1RMD A; 5KL7 A; 4M2Z A; 2JR1 A; 2M9A A; 1IQO A; 2UUB E; 4KHP E; 5CFF E; 1ZBT A; 4GKJ E; 5IV8 B; 2EOQ A; 2ZM6 E; 2ODR C; 2E5L E; 1F2I G; 2M7Q A; 1FKA E; 2RSI A; 2QVW A; 2EOE A; 1YFH A; 4DV7 E; 1EKZ A; 2EOH A; 2EOS A; 4KWY A; 2ELY A; 3J7A G; 2JY9 A; 2LE2 A; 4BC7 A; 1SFE A; 1U61 A; 2HC5 A; 4B3S E; 4BHC A; 4DV3 E; 1X48 A; 5T6J A; 3HTX A; 2JYA A; 2YTN A; 5A6B A; 2YU5 A; 1T39 A; 1TN9 A; 4M30 A; 1A1F A; 3ADG A; 3F6H A; 2EMK A; 2K7I A; 2WBU A; 4AQY E; 3EPL A; 4LTY A; 2UUA E; 4BS9 A; 5FLX C; 4JYA E; 1HNW E; 4DKK A; 2F4V E; 2G7H A; 4JI3 E; 1YYK A; 4LF6 E; 2EM3 A; 4Q35 B; 2WBT A; 3K6Q A; 1JK2 A; 4R8O A; 1XNQ E; 2NA2 A; 4DUY E; 3T1Y E; 2CTD A; 1Z1B A; 3IWD A; 1N33 E; 2FTX B; 2LJH A; 4R2S A; 3EPH A; 2NUE A; 2GPI A; 4R2A A; 2DLQ A; 2UXB E; 2NUF A; 2DGC A; 4LFA E; 2DRP A; 2EM0 A; 3O2R A; 2EPX A; 4X65 E; 2LUP B; 1P47 A; 2LUQ A; 1X6E A; 1UHZ A; 4MLV A; 2EOX A; 2GHF A; 1STU A; 2EL4 A; 2WBS A; 1UBD C; 2EL5 A; 4LF8 E; 1QU6 A; 1ZBQ A; #chains in the Genus database with same CATH homology 2FGG A; 2LMZ A; 4F54 A; 4X66 E; 2L3C A; 4DV6 E; 2MC5 A; 4L5N C; 4BCA A; 3LLH A; 2EWL A; 1WXR A; 5A2Q C; 2MDR A; 5LMN E; 2GSL A; 2UXD E; 1IBM E; 3FIG A; 2RS7 A; 1X47 A; 3KWR A; 5F3W A; 2V86 A; 3HXL A; 1T4N A; 2KON A; 2N3H A; 2VF1 A; 2DMY A; 3J81 C; 2KOU A; 4NXN E; 2LTR A; 1X49 A; 2M4I A; 2FFL A; 4OOG C; 3ZOQ B; 3AUZ A; 3JTZ A; 5DNY A; 2LBS B; 2UXC E; 1YZ9 A; 3C4B A; 2LTS A; 1IBL E; 2CPN A; 3J80 C; 3OML A; 2F8B A; 4LF4 E; 2B3T B; 4X8W A; 3T1H E; 4X62 E; 3HPS A; 4DR6 E; 4JI0 E; 1WHQ A; 4DV1 E; 4GEQ B; 4WSP A; 1T4O A; 1WHN A; 2B7V A; 4F9B B; 2VQF E; 2UU9 E; 1DI2 A; 2JOX A; 3LML A; 2DIX A; 4KZS A; 2HHH E; 2RS6 A; 3JU0 A; 1GZ6 A; 1XMO E; 3IWC A; 4M2Z A; 2JOB A; 4K0K E; 2JR1 A; 2V83 A; 2MC6 A; 1JFZ A; 4LU9 A; 4YY3 E; 4DV2 E; 2UUB E; 4LFB E; 2DSY A; 4LF9 E; 4KHP E; 5CFF E; 2EB1 A; 1ZBT A; 3N3W A; 4GKJ E; 5AE1 A; 2ZM6 E; 1N34 E; 3ADL A; 2ODR C; 3RMP A; 4F9A B; 1HNX E; 4P7D A; 1FKA E; 1RC5 A; 2M7Q A; 1DQ3 A; 1HR0 E; 2E5L E; 2B9D A; 2QVW A; 4WYQ B; 4DV7 E; 1EKZ A; 1T4L B; 2L8T A; 3J7A G; 1YYO A; 2JY9 A; 2LE2 A; 2N3G A; 4M0V A; 4BC7 A; 1U61 A; 4B3S E; 4J8Z A; 4DV3 E; 4R03 A; 1X48 A; 4DR2 E; 5T6J A; 1GQE A; 4LF7 E; 3ADI A; 3HTX A; 4YHH E; 4NXM E; 4OX9 E; 5LL6 R; 4JI1 E; 3RV1 A; 2JWO A; 2VQE E; 1J5E E; 4DR1 E; 1RQ0 A; 3AV0 A; 3C4T A; 5ADZ A; 4DR4 E; 4M30 A; 4I8O A; 4L8N A; 4DR5 E; 2E1M A; 2VE7 C; 4JI8 E; 2KHX A; 5AE2 A; 5IWA E; 4TUI A; 2L3J A; 4DR3 E; 4X64 E; 3ADG A; 3F6H A; 4JI5 E; 4JI7 E; 1UIL A; 4DV0 E; 4Q28 A; 2H36 X; 2V85 A; 4JV5 E; 1I4S A; 2NUG A; 3VYY A; 4LFC E; 3VYX A; 4AQY E; 2L2N A; 4DUZ E; 4P78 A; 2UUC E; 4LTY A; 2L2M A; 2UUA E; 4BS9 A; 5FLX C; 2JVA A; 4B3T E; 1FJG E; 4JYA E; 1HNW E; 2V87 A; 3JAM C; 4DKK A; 2L92 A; 2YZT A; 4BC9 A; 2F4V E; 2RTX A; 3O2R B; 3RV0 A; 2G7H A; 2ODR D; 1YYK A; 3IWB A; 1XMQ E; 4JI3 E; 2V88 A; 4LF6 E; 4WPY A; 3J7Y p; 5LMU E; 2DB2 A; 1IBK E; 2WZO A; 1RC7 A; 1O0W A; 3K6Q A; 4DMI A; 5AE3 A; 2FV4 B; 2YT4 A; 4R8O A; 1XNQ E; 1J26 A; 4JI6 E; 4DR7 E; 1YYW A; 2NA2 A; 5BR8 E; 2LRS A; 1SR9 A; 4WFT A; 4DUY E; 4DV5 E; 3T1Y E; 1I94 E; 4JI2 E; 1N32 E; 3F6G A; 2V89 A; 3IWD A; 1N33 E; 2EZ6 A; 3HQ1 A; 1N36 E; 1PKP A; 4JI4 E; 2FTX B; 2V8Q B; 3MSW A; 2LJH A; 2M1S A; 2NUE A; 2UXB E; 3H09 A; 5IT9 C; 2K4V A; 2NUF A; 3DJW A; 5AAS A; 4TUG A; 4LFA E; 2A11 A; 2L2K B; 1HNZ E; 3ADJ A; 3O2R A; 4X65 E; 4F9C B; 2LUP B; 4LF5 E; 2IHR 1; 4BMJ A; 3P1X A; 1XNR E; 2LUQ A; 2L6M A; 3VK6 A; 2L33 A; 1UHZ A; 4GKK E; 2RSM A; 4OUN A; 1STU A; 4B3M E; 4DV4 E; 2B7T A; 4B3R E; 3HPZ A; 3OTO E; 3DF6 A; 4LF8 E; 1QU6 A; 1ZBQ A; 4BBY A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
