2NPUA

The solution structure of the rapamycin-binding domain of mtor (frb)
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
101
structure length
101
Chain Sequence
MELIRVPILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords FKBP12-rapamycin complex-associated protein
publication title Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
pubmed doi rcsb
source organism Homo sapiens
total genus 28
structure length 101
sequence length 101
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2006-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08771 FRB_dom FKBP12-rapamycin binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.120.150 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) FKBP12-rapamycin binding domain 2npuA00
1FAPB 4FAPB 4DRIB 2NPUA 2RSEB 4DRJB 4DRHB 5GPGB 1AUEA 2FAPB 3FAPB 1NSGB 2GAQA
chains in the Genus database with same CATH superfamily
1XWJA 5E3CA 3O55A 1K04A 3V5ZA 2RSEB 4I44A 5E3AA 1YYXA 2C04A 2C03A 2CCYA 4DOZA 1ZW2A 3CQZA 5DS6A 2GFHA 3DMDA 1GM5A 1SF8A 3CEXA 3QZCA 5L0HA 5COGA 1LIHA 4EKWA 1E85A 4KNVA 5HV9A 2YLIA 2ZD9A 1RKCA 3FOOA 2QE9A 4P6IC 2EPNA 1YYJA 4P9FA 4ULVA 1OCRC 1BBHA 4LLCA 3I5QA 3OA1A 2A0UA 1OCOC 1OW7A 3DJNB 5AC5A 4P9TA 2GAQA 4YT4A 4OIPF 3UNGC 3WODF 1R4TA 2LQGA 1TWGA 3KH2A 4LACB 1V55C 2LD6A 4A2NB 2Q4FA 3GEIA 4OIQF 4WGYA 3U5SA 4ZLCA 1N1CA 2IXNA 3K1HA 2Z15A 2KSFA 4PJLA 3HNLA 4OIRF 5JT4A 4Q7CA 2ETSA 2XSEA 5F28E 5KYUA 3VAYA 2L7AA 3DM9B 5COMA 4DRHB 5EGYA 1VOMA 1J8YF 3U2MA 2V26A 3F47A 2R02A 4KNWA 1FTSA 1NLXA 2WZGA 3KYJA 3L1MA 4MTFA 2R7XA 4DRJB 3RQEA 2Q9BA 1M57C 2VCAA 2NUTB 2HV6A 2YVKA 4Z9HA 2HSQA 4IARA 4JEBA 2OG2A 1O5HA 1UG7A 2XS1A 3GWLA 1AUEA 2R7SA 2OOCA 3DM5A 4ONSA 2HJ3A 3FHDA 3LS1A 5T3TA 4YT5A 2Q9CA 3JSZA 3MX3A 2A68F 3SNHA 3KPHA 1Z3IX 1T9KA 1XZPA 3EGDA 1BR4A 4J30B 4JC7A 1UFBA 2XLDA 3N24A 2KYHA 3S0XA 2XLMA 3KYIA 4U5HA 1MMGA 1YJGA 2R7WA 2BE5F 4Z9JA 2JD3A 4OIOF 3NMJA 1LI7A 1KNYA 3IEEA 4IRUA 2KK1A 5E2QA 4JIOA 4CS9A 1VMAA 2WVNA 4FESA 3S29A 2DGJA 1HMDA 1JRAA 2O9XA 1D1CA 1H7IA 4GYTA 1O3UA 1SMYF 5D91A 3U3FA 1Q0DA 1D0YA 2XLWA 3ZDLA 4PFOA 4CJOA 3T9OA 4IAOA 4HEAJ 4FWVA 2PFDA 4ER9A 1KU2A 2J0XA 4GQHA 2XRHA 2P61A 3HTKC 4QI2A 5BQGA 3Q6MA 1MMAA 2PBEA 4YJWA 4CSAC 2L9JA 4KI2A 3EFOA 4LDKA 2XL6A 3SXYA 3ZIBA 1I4ZA 2Y39A 4MVZA 4XLPF 4U5FE 1APCA 1YVIA 4BEMJ 2CYDA 4BEJA 4Q4ZF 4JW1A 1Q0GA 1LS1A 3LLIA 3DKAA 3AGTA 3U9JA 2YRFA 1LE2A 1ZHTA 3L8JA 5E33A 1HE1A 5L3QA 3FDQA 2EPLX 2MWQA 5T1DB 3TJ5A 3C62A 1RJ9A 4NY3A 3EH1A 3H2VA 1D0XA 2ASRA 1E86A 1PD0A 2HMZA 3US6A 4DVZA 4JTAB 3TK0A 5L3VA 3LEVA 2OQMA 1TWCA 1BR2A 1EA8A 3GM2A 4JTCB 3RKOF 1U89A 1B68A 2AWYA 3EZIA 3LNMB 2J7PD 3NYJA 1M56C 2R7UA 3K1IA 2R7QA 3ZTZA 2WVOA 3RFYA 4NTAA 4YT8A 5KYWA 3RVZA 3AGUA 5D92A 2P1AA 2BL2A 3GORA 3JRMO 3JYHA 2GA0A 1H6GA 3EGXA 4CDYA 3B0VC 1T6UA 2EPMX 3IQCA 4N4WA 3POVA 2XL4A 4D4XA 5COFA 4CX9A 2R7VA 2KW3C 4J7YA 4HFFB 1A41A 3JT1A 5DS5A 1YDIA 3FVYA 4HFKB 1RKEB 2CGEA 1Q0FA 3C63A 2UUHA 3RF3A 1H9TA 4R32A 5F5FA 2Y3BA 5JSLA 1KTMA 3AQBA 1EI7A 3U2LA 3RQFA 4BJ5A 4YN0B 4B6IA 1FMWA 3J06A 1YA9A 1VK5A 4JTDB 1M6TA 3FAPB 2YL3A 2I15A 3DE9A 4N6HA 1OQCA 2QLAA 3M15A 3AG3C 1QVXA 4IJJA 1YA7O 4U5EE 4DXWA 2CDQA 1RXQA 2XXAA 2YLGA 3NMIA 4CS9C 3QW0A 3LEOA 2Y3DA 1A7DA 3TULA 1Z6AA 3LAYA 1L7CA 3O10A 4XPXA 5KYXB 4JRZA 3GANA 4L6RA 4MW8A 2YL0A 3LLKA 1E83A 2HV7A 1YARO 3RYLA 3UGOA 5B1AC 1RKEA 2ZXPA 5A6AA 3EJNA 1ZYRF 2YQYA 4EUKB 1ZU5A 1LM3B 1NBBA 2FAPB 1IZMA 1NSGB 5TJ5E 2YEVA 4BJ6A 3R7CA 3DWWA 3B9QA 2NPUA 1LS4A 2PX0A 3MFNA 4NTBA 4E17A 3HKKA 1OKKD 5FCLA 5L0FA 4XEVA 1VYKA 1BR1A 3U8VA 4K0DA 3DJUB 4MTOA 3JYYA 4Z9IA 5A6BA 4PFPA 2QY9A 1F1MA 1M2VB 1A0BA 2OU6A 3DZAA 4U5BE 4E7SA 4EWCA 3LS0A 5HSWA 4E18A 2L6FA 4N06A 1HW1A 2R9RB 3G4ZA 4XEFA 1R5ID 3PDMP 4JEAA 5B1BC 1NG1A 5JUAA 1TQGA 2FFHA 1FR0A 1HMOA 1QZXA 1JOGA 4G7HF 1CGNA 2MHRA 2R7TA 1JAFA 4HE8D 5DQZA 4O6NA 1ZW3A 2EINC 4QI0A 4DBRA 5DS4A 3JRTA 1U6HA 2NUPB 2J9UA 2OCCC 3K6BA 3ECSA 2LSEA 2YZSA 4OINF 1VLTA 5F5HA 1HY5A 2IBFA 4O79A 4NCQA 4CIHA 2AWCA 2IXMA 1G4WR 5CI8A 1TFOB 4BPMA 3NYLA 2A1DD 3R2PA 2H7OA 3HNKA 4D4NA 2V3CC 4AE4B 3NMKA 2J9WA 5L0DA 4U5GA 3G50A 1LI5A 2Q00A 2KC3A 3FMSA 4PR9A 3L34A 5L0IA 3GM1A 1LE4A 3QMKA 1S05A 2J7PA 4JE9A 1ZHXA 3AQCA 2NUTA 3RW0A 1T6IA 1BZ4A 4BJTA 3RQGA 5CIVA 3W4YA 1SYQA 3ZVRA 2P0NA 3S28A 2IXOA 4BJ5C 4U9DA 4PJNA 1WOLA 2OJED 5A6BD 3C8GB 4GEHA 3ABKC 4MVUA 3ZWIA 3B0UX 1ORJA 2H8AA 2J46A 1QSPA 3LNRA 4JJFA 2J9BA 4RD9A 2VB6A 4RDAA 1ZZPA 2PF4E 5EK0A 2OJQA 4O7GA 4CS7A 3GEEA 3ZSUA 3KKBA 1ZHZA 5A6JA 5JVEA 2I8BA 3SXZA 5DQTA 2WVQA 3Q7GA 2A69F 2XLOA 3IQTA 3OEOA 3V7OA 4AE4A 2AP3A 5GPGB 1VLSA 1Q0KA 1D1AA 4AX2A 1J8MF 1SZIA 3RVYA 3T6BA 1GGQA 2WL8A 3GEHA 3QVYA 4I1OB 3U8PA 4JCHA 1T01A 1WTYA 2ZXOA 1NFNA 2OEVA 2VCCA 4CDAA 3ASOC 2KQ9A 1NZEA 3O39A 3SXMA 1Y4CA 4KC9A 4G7ZF 1NFOA 2VASA 3F46A 4OD4A 1AVOB 2YLDA 1AEPA 3AOUA 3ASNC 1S7ZA 4PK4A 4BJ6C 4MVRA 2HMQA 1OCCC 3B0PA 3JTLO 3ZG1A 1DOVA 2DI3A 4YL0A 4AL1A 4LDRA 3H65A 1ZU4A 2A0BA 4X0RA 1LVKA 2LCHA 4MS2A 3SZRA 3U3BA 5JP7A 4EIYA 3UMIA 4XLNF 3I5PA 1TR2A 2KGOA 5L0JA 3C8ZA 1GS9A 3EPVA 2YWAA 1C03A 4JURI 3KL4A 3B71A 2R03A 3SEOA 3AG1C 4MTGA 5T3WA 1YZCA 1OKKA 4MVOA 3LESA 2J0WA 3ZTMA 4JZAA 3I4UA 1CGME 1EQ1A 2PP4A 1JPNA 2HS5A 1YZAA 3O6XA 1D0ZA 3H2UA 3MYIA 3QW1A 2HKVA 1CPRA 4YWQA 2D4UA 2P7VA 2Q7RA 256BA 3L0IA 5BUOA 2IYLD 1C17M 2OEXA 2WB7A 3EG9B 3TQOA 2F22A 2XL8A 3M1CB 2LFFA 4G0HA 3MLGA 2LP4A 2TMVP 1RMVA 4NQFA 1CPQA 1E84A 3W2WA 4LDQA 3QVZA 2HZ8A 2L6HA 1DOWA 3DI5A 3SP1A 2YKZA 3MYFA 2DYRC 2PX3A 4CBEA 4MQ9F 4MVMA 2CNWD 2YL7A 3ABMC 4MVSA 1A7VA 3IQ6A 4M63A 4XWJA 3VYWA 1K05A 3T6JA 1ZHYA 4AL0A 3C8GD 1G8XA 4C3DA 1XZQA 3CZ6A 3PCVA 4A4AA 1Z63A 3CSKA 4O6YA 1VYIA 3VRCA 2Y3GA 3WG7C 4DJ9A 1OR2A 1L3PA 3ABLC 3A11A 2IOQA 3IPMO 3HNIA 4H54A 2MYSA 2ZXRA 3ZQVA 2DB4A 1WWPA 3NYMA 2X0CA 1LKXA 4G7OF 2VC9A 3GODA 3DAGA 1T6QA 2QUPA 4I3MA 1WASA 3UGPA 3UR3C 4LLEA 5BQIA 3W2VA 3Q7LA 4JJGA 4CJGA 5A69A 1WGWA 3DE8A 3JZ0A 4CSAA 1IW7F 2NG1A 4CDVA 1V4AA 2EIJC 5FZTA 2IXPA 3K7DA 4BJ1A 4EBKA 5KYUB 1FMVA 3U9MA 4K1OA 4I1MA 3HNJA 3AJMA 1JMWA 2JX0A 4RBNA 2IM8A 4MNDA 1OW6A 1RCPA 3ITFA 1G4US 1G5ZA 3N0TA 1ZHWA 3LJBA 3Q6NA 3CAXA 4AK9A 2Y3HA 5KYYB 3JSEO 2B0HA 4XTKA 4ANJA 2LFDA 5KYXA 1ORSC 3NKDA 3LUTB 3FXHA 2EILC 3RIPA 4IAQA 2QNLA 1PCXA 1QPUA 4LERA 3EH2A 2P6VA 2QTVA 2Q9AA 4YT2A 2Y69C 5EHHA 1TKNA 2W4MA 3EGDB 2KNHA 1YAUO 2OKUA 3DAFA 1CGOA 4WJ0A 3OWTA 1V74B 3K1IC 2B0JA 2D5RB 4CS8A 2WZFA 3KMIA 3NG1A 1QKRA 2R25A 2A6HF 4ULWA 4ZLDA 3T6GB 1M2VA 4EBBA 5DLJA 4E0IA 2E87A 4W8KA 1V54C 1I5NA 1Z5ZA 2HJMA 4J7TA 2CW0F 5KYYA 1M2OA 1QLEC 4PJMA 2Q3TA 4PACA 4C3BA 2HUJA 4OD5A 4FX5A 4UDVA 3NDBB 1FFHA 4U5DE 3L8IA 1NU9C 1W2WA 2M4EA 4MVQA 3S9OA 3AG4C 1GQAA 4U5CE 4DVYP 1ORYA 4E7ZA 3RH3A 5DVWA 2NUPA 5JRAA 1A7EA 3IQ5A 2RD9A 4K7BA 1MMNA 4NTFA 1Q0MA 3HJCA 3EFOB 3B29A 4XEKA 3FOPA 1H9GA 2J45A 1PD1A 1C02A 1TWHA 2AVKA 3HLZA 2HFIA 1O87A 2YL1A 2NSFA 1FAPB 3S27A 4KBLA 3GWNA 1LPEA 2G3VA 2L6GA 5A6KA 1WATA 1OXKA 4F4BA 4FAPB 2AU5A 1RJ9B 4H4KC 4MW3A 1MNEA 4E0HA 3TD7A 2GWWA 1I4YA 1QQ3A 4JCZA 3BEHA 2CNWA 1OR3A 2PNOA 5JS5A 1TWAA 1WN0A 2EPKX 2EPOA 5KYNA 2XS8A 1JPJA 2ZPAA 3C8GA 3N2ZB 3K33A 3TOMA 3PHF2 3K66A 4Q5SF 2GDCA 2XLVA 2JPUA 2VCBA 4NC3A 3UMHA 3WAQA 4N6CA 5K0IA 3WHNA 4WABA 2M64A 2R05A 3E9VA 3EHMA 3MBGA 1BDJB 2YHSA 3VM6A 3GM3A 4G78A 3X2QC 5KYWB 1OW8A 2G3KA 4EBJA 2FGYA 3M79A 5B3SC 3FAJA 2H7VC 4WGZA 1PV3A 1ZVZA 1Y6DA 3EZHA 5AGFA 3VF0A 3EGXB 1TFKB 4EHPA 3W8HA 2HSBA 2LIGA 1T5OA 1U0BB 5IY5C 1K40A 2W9YA 4IGGA 2X51A 3C18A 2LK4A 3A9CA 3NKEA 4PJJA 1FFTC 4O6MA 3PMRA 3NRHA 4C7OB 4BG0A 2BC5A 3DD7A 2EIMC 3S84A 4DBQA 3AG2C 2XLHA 5B3IA 1MNDA 1NU7D 4XPWA 1VB5A 1EKYA 4IB4A 2J9VA 1Z7Qc 4W8PA 3TOLA 2A6EF 3EQLF 1HE9A 2XM0A 4U9EA 4JVSA 3ATPA 1E2XA 4CS8C 5AC4A 1YLMA 2XLEA 3M4CA 3V5XA 3S90A 2WZLA 3EHNA 4CIPA 3M4BA 3C7JA 3BRJA 4DRIB 2ICWG 5BQHA 1D1BA 3DXJF 3T4RA 2J8WA 5L0CA 1OCZC 1HW2A 2XXAB 3G4XA 2EIKC 1FNTc 4YL3A 2UUIA 3V5YA 1VTMP 3QTHA 2L81A 4IWBA 2R7RA 5JLIA 3UMKA 3JCUQ 1OXBA 4XPYA 3ZC4A 4C7OA 5L0GA 4QDLA 3W8IA 3E70C 4J32B 4JKVA 4XQ1A 3ZQYA 3SXKA 4C3EA 1JR8A 1Z23A 2KJGA 2G62A 2NSGA 2ZXWC 1ST6A 2XM4A 2H7BA 3EG9A 5CI9A 1MMDA 3U0CA 4YK5A 1MQVA 2W45A 2VH3A 2W4BA 3IHUA 3SYNA 3X1OA 3TJ6A 2DYSC 2R7OA 4YL1A 1SR2A
chains in the Genus database with same CATH topology
1FAPB 4FAPB 4DRIB 2NPUA 2RSEB 4DRJB 4DRHB 5GPGB 1AUEA 2FAPB 3FAPB 1NSGB 2GAQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FAP B;  4FAP B;  4DRI B;  2NPU A;  2RSE B;  4DRJ B;  4DRH B;  5GPG B;  1AUE A;  2FAP B;  3FAP B;  1NSG B;  2GAQ A; 
#chains in the Genus database with same CATH topology
 1XWJ A;  5E3C A;  3O55 A;  1K04 A;  3V5Z A;  2RSE B;  4I44 A;  5E3A A;  1YYX A;  2C04 A;  2C03 A;  2CCY A;  4DOZ A;  1ZW2 A;  3CQZ A;  5DS6 A;  2GFH A;  3DMD A;  1GM5 A;  1SF8 A;  3CEX A;  3QZC A;  5L0H A;  5COG A;  1LIH A;  4EKW A;  1E85 A;  4KNV A;  5HV9 A;  2YLI A;  2ZD9 A;  1RKC A;  3FOO A;  2QE9 A;  4P6I C;  2EPN A;  1YYJ A;  4P9F A;  4ULV A;  1OCR C;  1BBH A;  4LLC A;  3I5Q A;  3OA1 A;  2A0U A;  1OCO C;  1OW7 A;  3DJN B;  5AC5 A;  4P9T A;  2GAQ A;  4YT4 A;  4OIP F;  3UNG C;  3WOD F;  1R4T A;  2LQG A;  1TWG A;  3KH2 A;  4LAC B;  1V55 C;  2LD6 A;  4A2N B;  2Q4F A;  3GEI A;  4OIQ F;  4WGY A;  3U5S A;  4ZLC A;  1N1C A;  2IXN A;  3K1H A;  2Z15 A;  2KSF A;  4PJL A;  3HNL A;  4OIR F;  5JT4 A;  4Q7C A;  2ETS A;  2XSE A;  5F28 E;  5KYU A;  3VAY A;  2L7A A;  3DM9 B;  5COM A;  4DRH B;  5EGY A;  1VOM A;  1J8Y F;  3U2M A;  2V26 A;  3F47 A;  2R02 A;  4KNW A;  1FTS A;  1NLX A;  2WZG A;  3KYJ A;  3L1M A;  4MTF A;  2R7X A;  4DRJ B;  3RQE A;  2Q9B A;  1M57 C;  2VCA A;  2NUT B;  2HV6 A;  2YVK A;  4Z9H A;  2HSQ A;  4IAR A;  4JEB A;  2OG2 A;  1O5H A;  1UG7 A;  2XS1 A;  3GWL A;  1AUE A;  2R7S A;  2OOC A;  3DM5 A;  4ONS A;  2HJ3 A;  3FHD A;  3LS1 A;  5T3T A;  4YT5 A;  2Q9C A;  3JSZ A;  3MX3 A;  2A68 F;  3SNH A;  3KPH A;  1Z3I X;  1T9K A;  1XZP A;  3EGD A;  1BR4 A;  4J30 B;  4JC7 A;  1UFB A;  2XLD A;  3N24 A;  2KYH A;  3S0X A;  2XLM A;  3KYI A;  4U5H A;  1MMG A;  1YJG A;  2R7W A;  2BE5 F;  4Z9J A;  2JD3 A;  4OIO F;  3NMJ A;  1LI7 A;  1KNY A;  3IEE A;  4IRU A;  2KK1 A;  5E2Q A;  4JIO A;  4CS9 A;  1VMA A;  2WVN A;  4FES A;  3S29 A;  2DGJ A;  1HMD A;  1JRA A;  2O9X A;  1D1C A;  1H7I A;  4GYT A;  1O3U A;  1SMY F;  5D91 A;  3U3F A;  1Q0D A;  1D0Y A;  2XLW A;  3ZDL A;  4PFO A;  4CJO A;  3T9O A;  4IAO A;  4HEA J;  4FWV A;  2PFD A;  4ER9 A;  1KU2 A;  2J0X A;  4GQH A;  2XRH A;  2P61 A;  3HTK C;  4QI2 A;  5BQG A;  3Q6M A;  1MMA A;  2PBE A;  4YJW A;  4CSA C;  2L9J A;  4KI2 A;  3EFO A;  4LDK A;  2XL6 A;  3SXY A;  3ZIB A;  1I4Z A;  2Y39 A;  4MVZ A;  4XLP F;  4U5F E;  1APC A;  1YVI A;  4BEM J;  2CYD A;  4BEJ A;  4Q4Z F;  4JW1 A;  1Q0G A;  1LS1 A;  3LLI A;  3DKA A;  3AGT A;  3U9J A;  2YRF A;  1LE2 A;  1ZHT A;  3L8J A;  5E33 A;  1HE1 A;  5L3Q A;  3FDQ A;  2EPL X;  2MWQ A;  5T1D B;  3TJ5 A;  3C62 A;  1RJ9 A;  4NY3 A;  3EH1 A;  3H2V A;  1D0X A;  2ASR A;  1E86 A;  1PD0 A;  2HMZ A;  3US6 A;  4DVZ A;  4JTA B;  3TK0 A;  5L3V A;  3LEV A;  2OQM A;  1TWC A;  1BR2 A;  1EA8 A;  3GM2 A;  4JTC B;  3RKO F;  1U89 A;  1B68 A;  2AWY A;  3EZI A;  3LNM B;  2J7P D;  3NYJ A;  1M56 C;  2R7U A;  3K1I A;  2R7Q A;  3ZTZ A;  2WVO A;  3RFY A;  4NTA A;  4YT8 A;  5KYW A;  3RVZ A;  3AGU A;  5D92 A;  2P1A A;  2BL2 A;  3GOR A;  3JRM O;  3JYH A;  2GA0 A;  1H6G A;  3EGX A;  4CDY A;  3B0V C;  1T6U A;  2EPM X;  3IQC A;  4N4W A;  3POV A;  2XL4 A;  4D4X A;  5COF A;  4CX9 A;  2R7V A;  2KW3 C;  4J7Y A;  4HFF B;  1A41 A;  3JT1 A;  5DS5 A;  1YDI A;  3FVY A;  4HFK B;  1RKE B;  2CGE A;  1Q0F A;  3C63 A;  2UUH A;  3RF3 A;  1H9T A;  4R32 A;  5F5F A;  2Y3B A;  5JSL A;  1KTM A;  3AQB A;  1EI7 A;  3U2L A;  3RQF A;  4BJ5 A;  4YN0 B;  4B6I A;  1FMW A;  3J06 A;  1YA9 A;  1VK5 A;  4JTD B;  1M6T A;  3FAP B;  2YL3 A;  2I15 A;  3DE9 A;  4N6H A;  1OQC A;  2QLA A;  3M15 A;  3AG3 C;  1QVX A;  4IJJ A;  1YA7 O;  4U5E E;  4DXW A;  2CDQ A;  1RXQ A;  2XXA A;  2YLG A;  3NMI A;  4CS9 C;  3QW0 A;  3LEO A;  2Y3D A;  1A7D A;  3TUL A;  1Z6A A;  3LAY A;  1L7C A;  3O10 A;  4XPX A;  5KYX B;  4JRZ A;  3GAN A;  4L6R A;  4MW8 A;  2YL0 A;  3LLK A;  1E83 A;  2HV7 A;  1YAR O;  3RYL A;  3UGO A;  5B1A C;  1RKE A;  2ZXP A;  5A6A A;  3EJN A;  1ZYR F;  2YQY A;  4EUK B;  1ZU5 A;  1LM3 B;  1NBB A;  2FAP B;  1IZM A;  1NSG B;  5TJ5 E;  2YEV A;  4BJ6 A;  3R7C A;  3DWW A;  3B9Q A;  2NPU A;  1LS4 A;  2PX0 A;  3MFN A;  4NTB A;  4E17 A;  3HKK A;  1OKK D;  5FCL A;  5L0F A;  4XEV A;  1VYK A;  1BR1 A;  3U8V A;  4K0D A;  3DJU B;  4MTO A;  3JYY A;  4Z9I A;  5A6B A;  4PFP A;  2QY9 A;  1F1M A;  1M2V B;  1A0B A;  2OU6 A;  3DZA A;  4U5B E;  4E7S A;  4EWC A;  3LS0 A;  5HSW A;  4E18 A;  2L6F A;  4N06 A;  1HW1 A;  2R9R B;  3G4Z A;  4XEF A;  1R5I D;  3PDM P;  4JEA A;  5B1B C;  1NG1 A;  5JUA A;  1TQG A;  2FFH A;  1FR0 A;  1HMO A;  1QZX A;  1JOG A;  4G7H F;  1CGN A;  2MHR A;  2R7T A;  1JAF A;  4HE8 D;  5DQZ A;  4O6N A;  1ZW3 A;  2EIN C;  4QI0 A;  4DBR A;  5DS4 A;  3JRT A;  1U6H A;  2NUP B;  2J9U A;  2OCC C;  3K6B A;  3ECS A;  2LSE A;  2YZS A;  4OIN F;  1VLT A;  5F5H A;  1HY5 A;  2IBF A;  4O79 A;  4NCQ A;  4CIH A;  2AWC A;  2IXM A;  1G4W R;  5CI8 A;  1TFO B;  4BPM A;  3NYL A;  2A1D D;  3R2P A;  2H7O A;  3HNK A;  4D4N A;  2V3C C;  4AE4 B;  3NMK A;  2J9W A;  5L0D A;  4U5G A;  3G50 A;  1LI5 A;  2Q00 A;  2KC3 A;  3FMS A;  4PR9 A;  3L34 A;  5L0I A;  3GM1 A;  1LE4 A;  3QMK A;  1S05 A;  2J7P A;  4JE9 A;  1ZHX A;  3AQC A;  2NUT A;  3RW0 A;  1T6I A;  1BZ4 A;  4BJT A;  3RQG A;  5CIV A;  3W4Y A;  1SYQ A;  3ZVR A;  2P0N A;  3S28 A;  2IXO A;  4BJ5 C;  4U9D A;  4PJN A;  1WOL A;  2OJE D;  5A6B D;  3C8G B;  4GEH A;  3ABK C;  4MVU A;  3ZWI A;  3B0U X;  1ORJ A;  2H8A A;  2J46 A;  1QSP A;  3LNR A;  4JJF A;  2J9B A;  4RD9 A;  2VB6 A;  4RDA A;  1ZZP A;  2PF4 E;  5EK0 A;  2OJQ A;  4O7G A;  4CS7 A;  3GEE A;  3ZSU A;  3KKB A;  1ZHZ A;  5A6J A;  5JVE A;  2I8B A;  3SXZ A;  5DQT A;  2WVQ A;  3Q7G A;  2A69 F;  2XLO A;  3IQT A;  3OEO A;  3V7O A;  4AE4 A;  2AP3 A;  5GPG B;  1VLS A;  1Q0K A;  1D1A A;  4AX2 A;  1J8M F;  1SZI A;  3RVY A;  3T6B A;  1GGQ A;  2WL8 A;  3GEH A;  3QVY A;  4I1O B;  3U8P A;  4JCH A;  1T01 A;  1WTY A;  2ZXO A;  1NFN A;  2OEV A;  2VCC A;  4CDA A;  3ASO C;  2KQ9 A;  1NZE A;  3O39 A;  3SXM A;  1Y4C A;  4KC9 A;  4G7Z F;  1NFO A;  2VAS A;  3F46 A;  4OD4 A;  1AVO B;  2YLD A;  1AEP A;  3AOU A;  3ASN C;  1S7Z A;  4PK4 A;  4BJ6 C;  4MVR A;  2HMQ A;  1OCC C;  3B0P A;  3JTL O;  3ZG1 A;  1DOV A;  2DI3 A;  4YL0 A;  4AL1 A;  4LDR A;  3H65 A;  1ZU4 A;  2A0B A;  4X0R A;  1LVK A;  2LCH A;  4MS2 A;  3SZR A;  3U3B A;  5JP7 A;  4EIY A;  3UMI A;  4XLN F;  3I5P A;  1TR2 A;  2KGO A;  5L0J A;  3C8Z A;  1GS9 A;  3EPV A;  2YWA A;  1C03 A;  4JUR I;  3KL4 A;  3B71 A;  2R03 A;  3SEO A;  3AG1 C;  4MTG A;  5T3W A;  1YZC A;  1OKK A;  4MVO A;  3LES A;  2J0W A;  3ZTM A;  4JZA A;  3I4U A;  1CGM E;  1EQ1 A;  2PP4 A;  1JPN A;  2HS5 A;  1YZA A;  3O6X A;  1D0Z A;  3H2U A;  3MYI A;  3QW1 A;  2HKV A;  1CPR A;  4YWQ A;  2D4U A;  2P7V A;  2Q7R A;  256B A;  3L0I A;  5BUO A;  2IYL D;  1C17 M;  2OEX A;  2WB7 A;  3EG9 B;  3TQO A;  2F22 A;  2XL8 A;  3M1C B;  2LFF A;  4G0H A;  3MLG A;  2LP4 A;  2TMV P;  1RMV A;  4NQF A;  1CPQ A;  1E84 A;  3W2W A;  4LDQ A;  3QVZ A;  2HZ8 A;  2L6H A;  1DOW A;  3DI5 A;  3SP1 A;  2YKZ A;  3MYF A;  2DYR C;  2PX3 A;  4CBE A;  4MQ9 F;  4MVM A;  2CNW D;  2YL7 A;  3ABM C;  4MVS A;  1A7V A;  3IQ6 A;  4M63 A;  4XWJ A;  3VYW A;  1K05 A;  3T6J A;  1ZHY A;  4AL0 A;  3C8G D;  1G8X A;  4C3D A;  1XZQ A;  3CZ6 A;  3PCV A;  4A4A A;  1Z63 A;  3CSK A;  4O6Y A;  1VYI A;  3VRC A;  2Y3G A;  3WG7 C;  4DJ9 A;  1OR2 A;  1L3P A;  3ABL C;  3A11 A;  2IOQ A;  3IPM O;  3HNI A;  4H54 A;  2MYS A;  2ZXR A;  3ZQV A;  2DB4 A;  1WWP A;  3NYM A;  2X0C A;  1LKX A;  4G7O F;  2VC9 A;  3GOD A;  3DAG A;  1T6Q A;  2QUP A;  4I3M A;  1WAS A;  3UGP A;  3UR3 C;  4LLE A;  5BQI A;  3W2V A;  3Q7L A;  4JJG A;  4CJG A;  5A69 A;  1WGW A;  3DE8 A;  3JZ0 A;  4CSA A;  1IW7 F;  2NG1 A;  4CDV A;  1V4A A;  2EIJ C;  5FZT A;  2IXP A;  3K7D A;  4BJ1 A;  4EBK A;  5KYU B;  1FMV A;  3U9M A;  4K1O A;  4I1M A;  3HNJ A;  3AJM A;  1JMW A;  2JX0 A;  4RBN A;  2IM8 A;  4MND A;  1OW6 A;  1RCP A;  3ITF A;  1G4U S;  1G5Z A;  3N0T A;  1ZHW A;  3LJB A;  3Q6N A;  3CAX A;  4AK9 A;  2Y3H A;  5KYY B;  3JSE O;  2B0H A;  4XTK A;  4ANJ A;  2LFD A;  5KYX A;  1ORS C;  3NKD A;  3LUT B;  3FXH A;  2EIL C;  3RIP A;  4IAQ A;  2QNL A;  1PCX A;  1QPU A;  4LER A;  3EH2 A;  2P6V A;  2QTV A;  2Q9A A;  4YT2 A;  2Y69 C;  5EHH A;  1TKN A;  2W4M A;  3EGD B;  2KNH A;  1YAU O;  2OKU A;  3DAF A;  1CGO A;  4WJ0 A;  3OWT A;  1V74 B;  3K1I C;  2B0J A;  2D5R B;  4CS8 A;  2WZF A;  3KMI A;  3NG1 A;  1QKR A;  2R25 A;  2A6H F;  4ULW A;  4ZLD A;  3T6G B;  1M2V A;  4EBB A;  5DLJ A;  4E0I A;  2E87 A;  4W8K A;  1V54 C;  1I5N A;  1Z5Z A;  2HJM A;  4J7T A;  2CW0 F;  5KYY A;  1M2O A;  1QLE C;  4PJM A;  2Q3T A;  4PAC A;  4C3B A;  2HUJ A;  4OD5 A;  4FX5 A;  4UDV A;  3NDB B;  1FFH A;  4U5D E;  3L8I A;  1NU9 C;  1W2W A;  2M4E A;  4MVQ A;  3S9O A;  3AG4 C;  1GQA A;  4U5C E;  4DVY P;  1ORY A;  4E7Z A;  3RH3 A;  5DVW A;  2NUP A;  5JRA A;  1A7E A;  3IQ5 A;  2RD9 A;  4K7B A;  1MMN A;  4NTF A;  1Q0M A;  3HJC A;  3EFO B;  3B29 A;  4XEK A;  3FOP A;  1H9G A;  2J45 A;  1PD1 A;  1C02 A;  1TWH A;  2AVK A;  3HLZ A;  2HFI A;  1O87 A;  2YL1 A;  2NSF A;  1FAP B;  3S27 A;  4KBL A;  3GWN A;  1LPE A;  2G3V A;  2L6G A;  5A6K A;  1WAT A;  1OXK A;  4F4B A;  4FAP B;  2AU5 A;  1RJ9 B;  4H4K C;  4MW3 A;  1MNE A;  4E0H A;  3TD7 A;  2GWW A;  1I4Y A;  1QQ3 A;  4JCZ A;  3BEH A;  2CNW A;  1OR3 A;  2PNO A;  5JS5 A;  1TWA A;  1WN0 A;  2EPK X;  2EPO A;  5KYN A;  2XS8 A;  1JPJ A;  2ZPA A;  3C8G A;  3N2Z B;  3K33 A;  3TOM A;  3PHF 2;  3K66 A;  4Q5S F;  2GDC A;  2XLV A;  2JPU A;  2VCB A;  4NC3 A;  3UMH A;  3WAQ A;  4N6C A;  5K0I A;  3WHN A;  4WAB A;  2M64 A;  2R05 A;  3E9V A;  3EHM A;  3MBG A;  1BDJ B;  2YHS A;  3VM6 A;  3GM3 A;  4G78 A;  3X2Q C;  5KYW B;  1OW8 A;  2G3K A;  4EBJ A;  2FGY A;  3M79 A;  5B3S C;  3FAJ A;  2H7V C;  4WGZ A;  1PV3 A;  1ZVZ A;  1Y6D A;  3EZH A;  5AGF A;  3VF0 A;  3EGX B;  1TFK B;  4EHP A;  3W8H A;  2HSB A;  2LIG A;  1T5O A;  1U0B B;  5IY5 C;  1K40 A;  2W9Y A;  4IGG A;  2X51 A;  3C18 A;  2LK4 A;  3A9C A;  3NKE A;  4PJJ A;  1FFT C;  4O6M A;  3PMR A;  3NRH A;  4C7O B;  4BG0 A;  2BC5 A;  3DD7 A;  2EIM C;  3S84 A;  4DBQ A;  3AG2 C;  2XLH A;  5B3I A;  1MND A;  1NU7 D;  4XPW A;  1VB5 A;  1EKY A;  4IB4 A;  2J9V A;  1Z7Q c;  4W8P A;  3TOL A;  2A6E F;  3EQL F;  1HE9 A;  2XM0 A;  4U9E A;  4JVS A;  3ATP A;  1E2X A;  4CS8 C;  5AC4 A;  1YLM A;  2XLE A;  3M4C A;  3V5X A;  3S90 A;  2WZL A;  3EHN A;  4CIP A;  3M4B A;  3C7J A;  3BRJ A;  4DRI B;  2ICW G;  5BQH A;  1D1B A;  3DXJ F;  3T4R A;  2J8W A;  5L0C A;  1OCZ C;  1HW2 A;  2XXA B;  3G4X A;  2EIK C;  1FNT c;  4YL3 A;  2UUI A;  3V5Y A;  1VTM P;  3QTH A;  2L81 A;  4IWB A;  2R7R A;  5JLI A;  3UMK A;  3JCU Q;  1OXB A;  4XPY A;  3ZC4 A;  4C7O A;  5L0G A;  4QDL A;  3W8I A;  3E70 C;  4J32 B;  4JKV A;  4XQ1 A;  3ZQY A;  3SXK A;  4C3E A;  1JR8 A;  1Z23 A;  2KJG A;  2G62 A;  2NSG A;  2ZXW C;  1ST6 A;  2XM4 A;  2H7B A;  3EG9 A;  5CI9 A;  1MMD A;  3U0C A;  4YK5 A;  1MQV A;  2W45 A;  2VH3 A;  2W4B A;  3IHU A;  3SYN A;  3X1O A;  3TJ6 A;  2DYS C;  2R7O A;  4YL1 A;  1SR2 A; 
#chains in the Genus database with same CATH homology
 1FAP B;  4FAP B;  4DRI B;  2NPU A;  2RSE B;  4DRJ B;  4DRH B;  5GPG B;  1AUE A;  2FAP B;  3FAP B;  1NSG B;  2GAQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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