5AQQB

Fragment-based screening of hsp70 sheds light on the functional role of atp-binding site residues
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
111
structure length
106
Chain Sequence
SNSPQEEVELKKLKHLEKSVEKIADQLEELNKELTGIQQGFQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRLKRKGLVKKVQAFLAECDTVEQNICQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
pubmed doi rcsb
molecule tags Chaperone
source organism Homo sapiens
molecule keywords HEAT SHOCK COGNATE 71 KDA PROTEIN
total genus 44
structure length 106
sequence length 111
chains with identical sequence D, F
ec nomenclature
pdb deposition date 2015-09-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF02179 BAG BAG domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.58.120 Mainly Alpha Up-down Bundle Methane Monooxygenase Hydroxylase; Chain G, domain 1 BAG domain 5aqqB00
5AQIB 5AQOB 3FZLB 4HWFA 4HWHA 5AQNB 5AQGB 5AQMB 5AQTB 2D9DA 4HWIB 1UK5A 3M3ZB 5AQVB 3FZKB 3FZFB 5AQSB 5AQFB 3A8YC 1M62A 5AQKB 1HX1B 1I6ZA 5AQQB 1T7SA 4HWCA 5AQJB 3FZHB 3LDQB 1UGOA 5AQHB 1M7KA 4HWDA 5AQRB 5AQUB 3FZMB 5AQLB 5AQPB
chains in the Genus database with same CATH superfamily
2YDQA 3CX8B 3AE7A 3OJAA 2QA7A 2NW8A 2LSIA 2HHHT 2X68A 3ETVA 2EHOB 2DNXA 5FXWA 2LHRA 2X0HA 4LFCT 3AA1B 4X1IE 3UTKA 4OYKA 2WDRA 2K9AA 2KSRA 2I6HA 3KFWX 3ZYLA 1MNDA 2G0UA 2CLYC 5LP6E 2XQ3A 3K3OA 5J2UE 2N2NA 3EVYA 4X1YE 1XNQT 3CWZB 1N32T 4B3ST 3N9MA 4YHJA 2YN6A 3F31A 2XQ8A 2XAGB 4DVDA 4UVBB 3VU7H 2X0YA 4MALA 4IE0A 1ZHCA 2WQYA 4HWHA 4TWHA 4M1PA 2W0GA 3QNUA 5L3BB 4TV9E 3QC9A 4AQYT 2YU2A 1D0XA 3L3PA 4C91A 3ZCIA 3AA0B 4H9OC 3RRWA 3P4QA 4H63V 3FXEB 5ABEA 3PUXF 1UK5A 2LM2A 3RYIE 4K0UA 3R6NA 4A97A 3P50A 3OTOT 5AQSB 2ES0A 2K5BB 2XSAA 2LOPA 5AQQB 4YHHT 5AQJB 3WAKA 3AEGA 4I4TE 3ESLA 1XWMA 2GK9A 4KUMB 2BG9E 4LFAT 4EIWA 3N9PA 3KV4A 5HCMA 3RX6A 2V7JA 1MMNA 2YKSA 2P9BA 1T8BA 2BG9A 5LGUB 3H3AA 2OLTA 1W9RA 3NBXX 5LHHB 1IAPA 3KV9A 3PUZF 5FYMA 5IUXA 1FMVA 4H9PC 4GK5E 4CN1A 5EK2A 2HN1A 1VCSA 4JEUB 2L9QA 3CKDA 3AE4A 3HKCE 3ZN0B 5LG3A 3CX7B 3LFMA 3EDUA 4QH5A 4TNVA 1X9BA 1HX1B 3CVRA 5L4HA 2C5KT 5L3CB 3QK6A 2LLYA 2CPTA 3KBTA 4DV0T 2V26A 2E5VA 4EYYR 4X62T 3ZMTB 3DJBA 5E0OA 3CMLA 4JUYA 3ZKRA 2RP4A 2YDSA 3I9WA 3PUQA 2VVNA 3ZSSA 4UELA 4G2AA 3RYHE 4MFRA 1BR0A 3LK3B 3SWHA 2JJ9A 3RLFF 1D1BA 2DWGA 2WU2A 1US7B 1XDPA 2CLYB 5LGNB 2LSYA 3ZN1B 4U72A 3GN5B 3EI0A 2WDVA 2X9YA 3C64A 4AQFA 5JH7E 4U7IA 1GQEA 3CK6A 2E5LT 4ZS2A 1WR6A 2W2UA 4O4HE 2Y6XA 2LM9A 5AQHB 5IWAT 4EOZB 1SUMB 2KNDA 4DUZT 2UUCT 2WWUA 5HXEA 3NVOA 2IC6A 2V6YB 5JDMA 2KWHA 5CB4E 4ZZBA 4QX7B 4UV9B 3ETUA 4GIWA 3PV0F 4CZZB 3AA6B 2H7OA 2YINA 4P0AA 2W4XA 4H9NC 3ZC1A 3ZJ2A 3C98B 4QX8B 2KT9A 1OEDC 1G73A 5ABGA 4IDQA 2KWIB 1KFYA 3ZYKA 3T8OA 3ANWA 3UU4A 4PW8A 3O1JA 4HWCA 3EUHA 4DV5T 2XTLA 3AE6A 4EXTA 3Q5XA 2FJEA 4X66T 1Y01A 3H3MA 2Z6EA 4PNIA 2X51A 2WZHA 4G63A 3RPUA 5HAXA 3AXJB 5AFUL 2XAHB 1QSDA 3AEEA 3IHRA 1N33T 4CXYA 2JIWA 1KK7A 4LFBT 1YQ3A 4DR6T 4H9QC 2LJLA 5A1LA 2J47A 3NWIA 4DIDB 4HEAA 2L8KA 5TAOA 4U3CA 5CJ5A 3KBUA 2XQ5A 5JVDE 4JI4T 3AE8A 5HEJA 3RYFE 2KXPB 4ZI3C 1LVFA 5LGTB 2V6XA 2E9XD 4X20E 4LMJA 3AEFA 4ZZCA 4ZS3A 2H89A 4PJJA 2LOSA 3CQXC 2MOZA 5JDFA 4WNKA 5JRCA 3BQIA 5C2TA 1J5ET 1R8IA 2RA1A 5ADXL 2E9XA 4Q25A 3CQCB 2HPLA 5AQIB 1NENA 4HTEA 4IDPA 4IT4A 4OFZA 3LK42 1BR1A 3Q5WA 4HFEA 3N2OA 1E7PA 5HEHA 2LRLA 5F5WA 1WFDA 5CGMA 2YDRA 4L5GA 3NRXA 1LKXA 3BQKA 1OEDB 3UUNA 4IIJE 4B3RT 1IBKT 1YW0A 1HF8A 2X9XA 5CA1E 3IF8B 3RQWA 3D0TA 4I50E 1J1JA 4CXWA 3MK7C 4HFCA 2UXNB 2W62A 4IDNA 3JADA 1YD8G 2NR4A 3N9QA 1BR2A 1UGOA 1MMDA 2CA5A 3L8RA 4IDZA 2WDQA 1MIWA 2ACXA 4KHPT 1IBLT 3C4WA 4U2ZA 3N9OA 5AQVB 3TLTA 4U74A 2BDEA 2VVSA 3W15B 2UUAT 1G8XA 2D0UA 2CE7A 3VHLA 4O4JE 2IHR1 2VKJA 1XDOA 2VWAA 4ASKA 3PDYA 1NEKA 4JI6T 2RPAA 2MBGA 2UXBT 3ZMZB 4XZCA 2WZIA 4X1KE 3PUYF 2A3DA 3GMIA 1UCUA 5FMNA 2JMKA 3PUWF 3IEEA 3AECA 3ZLIA 2ZM8A 1LRZA 2QGSA 3VR9A 4YFSA 4AIUA 5C8YE 4F8HA 4KX6A 1H7CA 1HFAA 3Q2MA 2XM1A 4ZI2D 4FI5A 4ISTA 3EABA 4KBMB 3RF1A 3KV5A 3ZSTA 1UX5A 5H6QB 4AQGA 5FY7A 4YSXA 1V9DA 2JRKA 3RIAA 1T98A 3AAEB 4HFIA 4QXBB 4X64T 2ODUA 4U2YA 5LJMA 5FL0A 3J9X1 4DMVA 4ILBA 3AB3B 5IYZE 4DR7T 4ILUA 3UU6A 4YY3T 5FL1A 5ABFB 2QVAA 2A2FX 2DCFA 1T7SA 4HFVA 1Y64B 2UU9T 3LDQB 5FXZA 4UVAB 3ZMUB 1AJ3A 4JI8T 1KF6A 3O1HA 4LF4T 2IDOB 4XAXB 3TLSA 4DV7T 4GOUA 3PURA 4TV8E 1M62A 5LHGB 3AE3A 3UUBA 5CFBA 4UXNB 2FUPA 4PJNA 2LEHA 3LBXB 5H6RB 1OXZA 4AKRB 4IDOA 4AXPA 2CBJA 3PUGA 2XM2A 2JMHA 3N2KE 2W66A 4WW0A 5JR9A 1IJ6A 3I1AA 3OVUA 3ZCJA 1Z8UA 4QHOA 3N9NA 1SE7A 2PTFA 5JREA 2LSGA 5EK3A 5HYAA 2F4VT 3SOLA 4H9RC 4CXXA 2NOXA 3R84B 3AEAA 3JAFA 2H7VC 5AQRB 2BG9C 2J4GA 1VOMA 3FZLB 2CWYA 5HEGA 2R6GF 3SFEA 5F8PA 3FZFB 3Q5EA 4B3MT 3ZMSB 3PJAA 4YTPA 3P4RA 2J62A 2DHRA 2IC9A 4GKJT 3ZT6A 1X79A 5C3JA 5LOVE 5AQPB 5EK4A 2V1DB 1XMQT 4I55E 5FKYA 4HN9A 2WB5A 4IE7A 2Q9QD 4GYRA 3P8CD 3C4XA 5FVKA 1XMOT 1HTJF 4UF0B 5JDHA 4TUYE 4QH1A 2ZM6T 4LF6T 3U78A 4X65T 5DQWA 4JI7T 3QB5A 2Q9QA 2VKOA 2NW9A 3ONLC 4N78D 2XQ6A 4JYAT 2JQKA 2Y8DA 3E22E 1WLXA 5FVLA 2AE9A 3AE5A 4QWNB 4YTMA 3RH3A 2W63A 3DP7A 3A5XA 3FZHB 4O8SA 2CHOA 3MXZA 4U33A 4TNWA 2MTQA 3LK2B 2XASB 5EZYE 5GONE 1KNRA 2Y48B 4ERRA 3F57A 1Z0PA 2XUEA 2K24A 2ODVA 4LMKA 4UR9A 4LF7T 1L0VA 3RC8A 2EHOD 1KEYA 5LHIB 4CQIA 3O9XA 4A56A 4HWFA 3T1HT 4QXCB 1D1CA 1I94T 3AE9A 2PG8A 1MMGA 2WP9A 5LA6E 5FY0A 2JQQA 2CHNA 3ONXA 4TX5A 4O4IE 4YSYA 3ZJ1A 4EZ4A 3PUAA 2LRKA 1HNXT 4JI5T 5LBQB 1JNZA 2EHOA 5DJQC 4P1NA 3JC6D 4AKIA 2VASA 3RI5A 3A8YC 2V7KA 2HPJA 1D0ZA 1N36T 2X9WA 3MJXA 3IBPA 4A98A 1DU2A 2BG9B 3X1DA 3L09A 3TLUA 5AQGB 3L39A 1HG5A 2V5DA 2OV9A 4DMWA 3RIUA 3HR0A 5LBMA 4YLHA 1ZV4X 1WR0A 5JTGA 1ZP0A 4PK6A 4B6XA 4CI1B 5LMNT 3CQGB 4LMLA 4WZXA 1S35A 4TWFA 4YTNA 2NP9A 3NKZA 2CXDA 4COFA 4H9SE 3SS1A 4AKLA 5KXJA 1B7TA 1S94A 3RIFA 1KNPA 1M7KA 2V8SV 2I59A 1HX8A 3AVSA 1MIVA 1SA0E 4NXNT 4HGAA 3NZPA 3OPCA 3JCFA 3VRBA 1XNRT 4TWDA 3PUVF 3A7MA 3AAAB 4OHFA 4JI3T 2WSSV 3UU8A 1D0YA 4CN6A 4UIGA 4ZI7E 2XSBA 1D1AA 2ZM0A 2KLQA 4PJMA 1U4QA 2W67A 4O2BE 2M6IA 1KNZA 1OWAA 2SPCA 3FHNA 2QYWA 4L0RA 1FIOA 2UXCT 4DR2T 3O4XE 1UX4A 4PK4A 2XQ7A 3VKHA 2JPFA 1W0BA 5L3GB 3UT5E 5BMVE 5AQFB 1W0AA 2VKHA 4DV6T 3I0OA 2HH7A 4AKHA 1WYCA 1HNWT 4OX9T 2VL8A 3SRZA 2WU5A 5JDQA 5HEUA 1CUNA 2DL1A 1J5WA 1N34T 3BK9A 2E9XC 3ZT5A 1HS7A 5AQTB 3EDVA 2UUBT 4EGWA 3ZC0A 2D5UA 4AISA 5LJNA 4P09A 4Z8XA 2D2SA 4U31A 2VURA 4IREA 2JQHA 2IW5B 5LMUT 3GWHA 4HFDA 4P0BA 4ADZA 2LSJA 3QOFA 4HE8A 3ZEFB 4JLEA 4TN7B 2ZMAA 2XJ7A 2NTXA 2V7LA 3M65A 3OBVE 1EZ3A 2LKGA 5AQOB 4X5TA 2AXDS 4KP3C 3B57A 3GN5A 3NRYA 2VB6A 3ANWB 4WBOA 2CM0A 2W00A 2BBJA 4JBWF 2NWBA 3C51A 4FJOA 2XAJB 2HN2A 2DI4A 3FZMB 2C0SA 1VRBA 5L2LA 2E2AA 5DQVA 2IIUA 2X0LB 5J0ZA 5L3FB 2YU1A 2UXDT 4BAYB 3FBLA 2V6YA 4WYVA 2WMNA 3PU3A 4MBQA 3P7IA 4J2CA 3K1SA 1CHUA 1VCTA 3OKQA 5L4EA 4YSZA 1NWMX 2UXXB 3KVAA 1I6ZA 1HG2A 2I0MA 4EAHA 5KDMC 5J1GA 4BJMA 4GK0E 1ZOYA 2NW7A 4H63H 2XHEB 5ABHA 2FBWA 3Q9DA 5LYJE 3M3ZB 4YJ2E 2PBIA 4ANJA 3AE2A 4DV2T 4PAGA 4L9IA 2BS4A 1FMWA 3KINB 4ILCA 3FBZA 5FY1A 3RC3A 3PUSA 5DABA 4I0UA 2BBHA 3RHWA 3UFGA 5JDNA 4IL9A 4KHZF 3AE1A 3CX6B 2FJAA 3CPZA 1YQ4A 4ISSA 2KZ7B 1JNRA 5LB7B 2A9UA 2C5JA 2K48A 5JRCB 3EHZA 1NAFA 5HXHA 3PU8A 2V7MA 3HKDE 4GYSA 2E9XB 4EZHA 4JI2T 1IBMT 2XQ4A 3CIRA 4DO0A 1WYBA 5KMGP 4ZI2C 3AAIA 3MZKB 4IE6A 1YXRA 4B3TT 5FXXA 2FJDA 1IZNB 4DBQA 2VQFT 3AXJA 3C50A 2LT3A 2M6BA 5CA0E 2J1DG 3ABVA 2BKPA 2DWKA 4PK5A 3RYCE 3UU5A 3T1YT 2WM9A 4QH4A 4C90A 2CXFA 2WCAA 4JEHB 3UQ4A 5FP3A 3FXDB 2H3RA 1FEWA 5LXTE 2A72A 4YJ3E 2LHNA 5LNKA 3QUJA 4DV1T 3LG7A 5AQMB 2K3WA 2CMRA 3PJAJ 4YXDA 2IUBA 2ACZA 3B13A 1BR4A 2NTYA 3FB2A 4DR1T 2X9HA 3I9YA 4HWDA 4DNDA 5AQLB 4BJNA 3K8PC 2XAQB 1QLBA 5JR9C 4NUVA 2BKNA 2C5IT 2VL0A 4HFHA 2IMLA 5ETWA 4PJLA 3FZKB 3AA7B 4V1Av 1UUSA 3UULA 4O4LE 3N9LA 4E7SA 3EAMA 2YOEA 3AEDA 5FXVA 2ZM2A 2BZBA 2CCQA 2IAKA 2FJBA 2H88A 3WI3A 1OEDE 2E8IA 2XPKA 3RKGA 4KMCA 3HL6A 4I43B 5LG4A 5HCJA 3Q5DA 4IE5A 3UUXB 1O3XA 2LSKA 1OEDA 5HXSA 4ZXLA 5HXCA 1MNEA 4ILAA 2BVLA 1XZYA 1MIYA 1ZKEA 2YK0A 4DUYT 3K3QC 4HKAA 5LCYA 4CN4A 5KX5E 2KINB 3P4PA 2XZEA 3ZYMA 1HNZT 4PFOA 4NPPA 2QRXA 4BA9A 2B1EA 3UFEA 5L47A 4AQFC 5AQKB 4EEBA 3JAEA 5L3EB 3GA8A 4MHCA 2Q9QC 1HR0T 5AQUB 2WBLA 4EYUA 3KVBA 2N9DA 3J7Yq 3MA9A 4DBRA 3I0QA 2VK9A 4EV6A 3KDSE 2MPKA 2B76A 2WY2A 3LJCA 3HA4A 4A5XA 2KMFA 3VR8A 1LVKA 3N5LA 1YKHB 3K3NA 4IL4A 4ZI3D 3ZMVB 2BS2A 2L3LA 2CXLA 2D0TA 2CWOA 2WMOA 3RRCA 4TZ4C 3AEBA 2XY8B 4U7YA 2BS3A 5BR8T 5HEOA 5L3DB 4JV5T 3V5SA 4OK0A 1T72A 3U3IA 3OYXA 4ZEYA 3UQ7A 5FNVE 5HWYA 3N2GE 5IHYA 4ZOLE 3O1IA 4DR5T 4GKKT 4PFPA 4NXMT 2CEAA 4JI1T 1U5PA 1WCRA 4IE4A 1UURA 5JR9B 2V5CA 2BVMA 2EHOC 2VKDA 2CRBA 3RGLA 4CI2B 1HCIA 3AVRA 3TLVA 3S4UA 2XQ9A 2LKHA 2WWVA 1ZEEA 3MKDA 3BQLA 2YEVC 1SHZC 4KI0F 2WS3A 2WAUA 5ABFA 3MACA 5JDGA 3QB5K 3P4SA 4UVCB 3SFDA 1FJGT 4LF5T 1E1HB 3E0ZA 3JC6C 3RIUC 3UU3A 3ZT7A 3PTRB 4XBFB 4UEMA 2PJQA 1IJ5A 3TLWA 3E08A 5AQNB 3VRAA 5HXRA 4OYJA 2MAWA 2MYSA 3HKEE 3PE0A 4EB6E 1MMAA 3RKOA 1W09A 4UV8B 1E2AA 4E7ZA 4AKGA 4AI6A 2LE8A 3LBXA 2X67A 2OA5A 2XQYA 4ZHQE 2W61A 4HWIB 5M4YA 2CBIA 3VKGA 2V7IA 4IHJE 4NIQA 1YKEB 3DTOA 2Q9QB 4WBNE 2N1GA 2XQAA 4QXHB 5HWXA 1WRDA 4QKNA 2XAFB 2JQ9A 2X66A 3C4ZA 3P4WA 4DV3T 4LF9T 2M67A 4DR3T 3ZPOA 3LSVA 4EEDA 4NUUA 5F3JA 4HFBA 3KV6A 4YT0A 3NZQA 5JDLA 4Z91A 3B5MA 2ZLYA 2D9DA 4MLKA 3V5UA 3UUMA 3HI2A 3IA3A 3H37A 4F6RC 4O2AE 2PFVA 4IGUA 3F2EA 4DR4T 2VQET 3OYZA 4K0KT 3ONJA 3HKBE 3TKLB 4Z90A 3RQUA 4UF0A 4CI3B 4LF8T 4DV4T 5JQGE 2BKOA 2DLRA 5J2TE 4JI0T 3WAJA 3G06A 1QUUA
chains in the Genus database with same CATH topology
5AQIB 5AQOB 3FZLB 4HWFA 4HWHA 5AQNB 5AQGB 5AQMB 5AQTB 2D9DA 4HWIB 1UK5A 3M3ZB 5AQVB 3FZKB 3FZFB 5AQSB 5AQFB 3A8YC 1M62A 5AQKB 1HX1B 1I6ZA 5AQQB 1T7SA 4HWCA 5AQJB 3FZHB 3LDQB 1UGOA 5AQHB 1M7KA 4HWDA 5AQRB 5AQUB 3FZMB 5AQLB 5AQPB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5AQI B;  5AQO B;  3FZL B;  4HWF A;  4HWH A;  5AQN B;  5AQG B;  5AQM B;  5AQT B;  2D9D A;  4HWI B;  1UK5 A;  3M3Z B;  5AQV B;  3FZK B;  3FZF B;  5AQS B;  5AQF B;  3A8Y C;  1M62 A;  5AQK B;  1HX1 B;  1I6Z A;  5AQQ B;  1T7S A;  4HWC A;  5AQJ B;  3FZH B;  3LDQ B;  1UGO A;  5AQH B;  1M7K A;  4HWD A;  5AQR B;  5AQU B;  3FZM B;  5AQL B;  5AQP B; 
#chains in the Genus database with same CATH topology
 2YDQ A;  3CX8 B;  3AE7 A;  3OJA A;  2QA7 A;  2NW8 A;  2LSI A;  2HHH T;  2X68 A;  3ETV A;  2EHO B;  2DNX A;  5FXW A;  2LHR A;  2X0H A;  4LFC T;  3AA1 B;  4X1I E;  3UTK A;  4OYK A;  2WDR A;  2K9A A;  2KSR A;  2I6H A;  3KFW X;  3ZYL A;  1MND A;  2G0U A;  2CLY C;  5LP6 E;  2XQ3 A;  3K3O A;  5J2U E;  2N2N A;  3EVY A;  4X1Y E;  1XNQ T;  3CWZ B;  1N32 T;  4B3S T;  3N9M A;  4YHJ A;  2YN6 A;  3F31 A;  2XQ8 A;  2XAG B;  4DVD A;  4UVB B;  3VU7 H;  2X0Y A;  4MAL A;  4IE0 A;  1ZHC A;  2WQY A;  4HWH A;  4TWH A;  4M1P A;  2W0G A;  3QNU A;  5L3B B;  4TV9 E;  3QC9 A;  4AQY T;  2YU2 A;  1D0X A;  3L3P A;  4C91 A;  3ZCI A;  3AA0 B;  4H9O C;  3RRW A;  3P4Q A;  4H63 V;  3FXE B;  5ABE A;  3PUX F;  1UK5 A;  2LM2 A;  3RYI E;  4K0U A;  3R6N A;  4A97 A;  3P50 A;  3OTO T;  5AQS B;  2ES0 A;  2K5B B;  2XSA A;  2LOP A;  5AQQ B;  4YHH T;  5AQJ B;  3WAK A;  3AEG A;  4I4T E;  3ESL A;  1XWM A;  2GK9 A;  4KUM B;  2BG9 E;  4LFA T;  4EIW A;  3N9P A;  3KV4 A;  5HCM A;  3RX6 A;  2V7J A;  1MMN A;  2YKS A;  2P9B A;  1T8B A;  2BG9 A;  5LGU B;  3H3A A;  2OLT A;  1W9R A;  3NBX X;  5LHH B;  1IAP A;  3KV9 A;  3PUZ F;  5FYM A;  5IUX A;  1FMV A;  4H9P C;  4GK5 E;  4CN1 A;  5EK2 A;  2HN1 A;  1VCS A;  4JEU B;  2L9Q A;  3CKD A;  3AE4 A;  3HKC E;  3ZN0 B;  5LG3 A;  3CX7 B;  3LFM A;  3EDU A;  4QH5 A;  4TNV A;  1X9B A;  1HX1 B;  3CVR A;  5L4H A;  2C5K T;  5L3C B;  3QK6 A;  2LLY A;  2CPT A;  3KBT A;  4DV0 T;  2V26 A;  2E5V A;  4EYY R;  4X62 T;  3ZMT B;  3DJB A;  5E0O A;  3CML A;  4JUY A;  3ZKR A;  2RP4 A;  2YDS A;  3I9W A;  3PUQ A;  2VVN A;  3ZSS A;  4UEL A;  4G2A A;  3RYH E;  4MFR A;  1BR0 A;  3LK3 B;  3SWH A;  2JJ9 A;  3RLF F;  1D1B A;  2DWG A;  2WU2 A;  1US7 B;  1XDP A;  2CLY B;  5LGN B;  2LSY A;  3ZN1 B;  4U72 A;  3GN5 B;  3EI0 A;  2WDV A;  2X9Y A;  3C64 A;  4AQF A;  5JH7 E;  4U7I A;  1GQE A;  3CK6 A;  2E5L T;  4ZS2 A;  1WR6 A;  2W2U A;  4O4H E;  2Y6X A;  2LM9 A;  5AQH B;  5IWA T;  4EOZ B;  1SUM B;  2KND A;  4DUZ T;  2UUC T;  2WWU A;  5HXE A;  3NVO A;  2IC6 A;  2V6Y B;  5JDM A;  2KWH A;  5CB4 E;  4ZZB A;  4QX7 B;  4UV9 B;  3ETU A;  4GIW A;  3PV0 F;  4CZZ B;  3AA6 B;  2H7O A;  2YIN A;  4P0A A;  2W4X A;  4H9N C;  3ZC1 A;  3ZJ2 A;  3C98 B;  4QX8 B;  2KT9 A;  1OED C;  1G73 A;  5ABG A;  4IDQ A;  2KWI B;  1KFY A;  3ZYK A;  3T8O A;  3ANW A;  3UU4 A;  4PW8 A;  3O1J A;  4HWC A;  3EUH A;  4DV5 T;  2XTL A;  3AE6 A;  4EXT A;  3Q5X A;  2FJE A;  4X66 T;  1Y01 A;  3H3M A;  2Z6E A;  4PNI A;  2X51 A;  2WZH A;  4G63 A;  3RPU A;  5HAX A;  3AXJ B;  5AFU L;  2XAH B;  1QSD A;  3AEE A;  3IHR A;  1N33 T;  4CXY A;  2JIW A;  1KK7 A;  4LFB T;  1YQ3 A;  4DR6 T;  4H9Q C;  2LJL A;  5A1L A;  2J47 A;  3NWI A;  4DID B;  4HEA A;  2L8K A;  5TAO A;  4U3C A;  5CJ5 A;  3KBU A;  2XQ5 A;  5JVD E;  4JI4 T;  3AE8 A;  5HEJ A;  3RYF E;  2KXP B;  4ZI3 C;  1LVF A;  5LGT B;  2V6X A;  2E9X D;  4X20 E;  4LMJ A;  3AEF A;  4ZZC A;  4ZS3 A;  2H89 A;  4PJJ A;  2LOS A;  3CQX C;  2MOZ A;  5JDF A;  4WNK A;  5JRC A;  3BQI A;  5C2T A;  1J5E T;  1R8I A;  2RA1 A;  5ADX L;  2E9X A;  4Q25 A;  3CQC B;  2HPL A;  5AQI B;  1NEN A;  4HTE A;  4IDP A;  4IT4 A;  4OFZ A;  3LK4 2;  1BR1 A;  3Q5W A;  4HFE A;  3N2O A;  1E7P A;  5HEH A;  2LRL A;  5F5W A;  1WFD A;  5CGM A;  2YDR A;  4L5G A;  3NRX A;  1LKX A;  3BQK A;  1OED B;  3UUN A;  4IIJ E;  4B3R T;  1IBK T;  1YW0 A;  1HF8 A;  2X9X A;  5CA1 E;  3IF8 B;  3RQW A;  3D0T A;  4I50 E;  1J1J A;  4CXW A;  3MK7 C;  4HFC A;  2UXN B;  2W62 A;  4IDN A;  3JAD A;  1YD8 G;  2NR4 A;  3N9Q A;  1BR2 A;  1UGO A;  1MMD A;  2CA5 A;  3L8R A;  4IDZ A;  2WDQ A;  1MIW A;  2ACX A;  4KHP T;  1IBL T;  3C4W A;  4U2Z A;  3N9O A;  5AQV B;  3TLT A;  4U74 A;  2BDE A;  2VVS A;  3W15 B;  2UUA T;  1G8X A;  2D0U A;  2CE7 A;  3VHL A;  4O4J E;  2IHR 1;  2VKJ A;  1XDO A;  2VWA A;  4ASK A;  3PDY A;  1NEK A;  4JI6 T;  2RPA A;  2MBG A;  2UXB T;  3ZMZ B;  4XZC A;  2WZI A;  4X1K E;  3PUY F;  2A3D A;  3GMI A;  1UCU A;  5FMN A;  2JMK A;  3PUW F;  3IEE A;  3AEC A;  3ZLI A;  2ZM8 A;  1LRZ A;  2QGS A;  3VR9 A;  4YFS A;  4AIU A;  5C8Y E;  4F8H A;  4KX6 A;  1H7C A;  1HFA A;  3Q2M A;  2XM1 A;  4ZI2 D;  4FI5 A;  4IST A;  3EAB A;  4KBM B;  3RF1 A;  3KV5 A;  3ZST A;  1UX5 A;  5H6Q B;  4AQG A;  5FY7 A;  4YSX A;  1V9D A;  2JRK A;  3RIA A;  1T98 A;  3AAE B;  4HFI A;  4QXB B;  4X64 T;  2ODU A;  4U2Y A;  5LJM A;  5FL0 A;  3J9X 1;  4DMV A;  4ILB A;  3AB3 B;  5IYZ E;  4DR7 T;  4ILU A;  3UU6 A;  4YY3 T;  5FL1 A;  5ABF B;  2QVA A;  2A2F X;  2DCF A;  1T7S A;  4HFV A;  1Y64 B;  2UU9 T;  3LDQ B;  5FXZ A;  4UVA B;  3ZMU B;  1AJ3 A;  4JI8 T;  1KF6 A;  3O1H A;  4LF4 T;  2IDO B;  4XAX B;  3TLS A;  4DV7 T;  4GOU A;  3PUR A;  4TV8 E;  1M62 A;  5LHG B;  3AE3 A;  3UUB A;  5CFB A;  4UXN B;  2FUP A;  4PJN A;  2LEH A;  3LBX B;  5H6R B;  1OXZ A;  4AKR B;  4IDO A;  4AXP A;  2CBJ A;  3PUG A;  2XM2 A;  2JMH A;  3N2K E;  2W66 A;  4WW0 A;  5JR9 A;  1IJ6 A;  3I1A A;  3OVU A;  3ZCJ A;  1Z8U A;  4QHO A;  3N9N A;  1SE7 A;  2PTF A;  5JRE A;  2LSG A;  5EK3 A;  5HYA A;  2F4V T;  3SOL A;  4H9R C;  4CXX A;  2NOX A;  3R84 B;  3AEA A;  3JAF A;  2H7V C;  5AQR B;  2BG9 C;  2J4G A;  1VOM A;  3FZL B;  2CWY A;  5HEG A;  2R6G F;  3SFE A;  5F8P A;  3FZF B;  3Q5E A;  4B3M T;  3ZMS B;  3PJA A;  4YTP A;  3P4R A;  2J62 A;  2DHR A;  2IC9 A;  4GKJ T;  3ZT6 A;  1X79 A;  5C3J A;  5LOV E;  5AQP B;  5EK4 A;  2V1D B;  1XMQ T;  4I55 E;  5FKY A;  4HN9 A;  2WB5 A;  4IE7 A;  2Q9Q D;  4GYR A;  3P8C D;  3C4X A;  5FVK A;  1XMO T;  1HTJ F;  4UF0 B;  5JDH A;  4TUY E;  4QH1 A;  2ZM6 T;  4LF6 T;  3U78 A;  4X65 T;  5DQW A;  4JI7 T;  3QB5 A;  2Q9Q A;  2VKO A;  2NW9 A;  3ONL C;  4N78 D;  2XQ6 A;  4JYA T;  2JQK A;  2Y8D A;  3E22 E;  1WLX A;  5FVL A;  2AE9 A;  3AE5 A;  4QWN B;  4YTM A;  3RH3 A;  2W63 A;  3DP7 A;  3A5X A;  3FZH B;  4O8S A;  2CHO A;  3MXZ A;  4U33 A;  4TNW A;  2MTQ A;  3LK2 B;  2XAS B;  5EZY E;  5GON E;  1KNR A;  2Y48 B;  4ERR A;  3F57 A;  1Z0P A;  2XUE A;  2K24 A;  2ODV A;  4LMK A;  4UR9 A;  4LF7 T;  1L0V A;  3RC8 A;  2EHO D;  1KEY A;  5LHI B;  4CQI A;  3O9X A;  4A56 A;  4HWF A;  3T1H T;  4QXC B;  1D1C A;  1I94 T;  3AE9 A;  2PG8 A;  1MMG A;  2WP9 A;  5LA6 E;  5FY0 A;  2JQQ A;  2CHN A;  3ONX A;  4TX5 A;  4O4I E;  4YSY A;  3ZJ1 A;  4EZ4 A;  3PUA A;  2LRK A;  1HNX T;  4JI5 T;  5LBQ B;  1JNZ A;  2EHO A;  5DJQ C;  4P1N A;  3JC6 D;  4AKI A;  2VAS A;  3RI5 A;  3A8Y C;  2V7K A;  2HPJ A;  1D0Z A;  1N36 T;  2X9W A;  3MJX A;  3IBP A;  4A98 A;  1DU2 A;  2BG9 B;  3X1D A;  3L09 A;  3TLU A;  5AQG B;  3L39 A;  1HG5 A;  2V5D A;  2OV9 A;  4DMW A;  3RIU A;  3HR0 A;  5LBM A;  4YLH A;  1ZV4 X;  1WR0 A;  5JTG A;  1ZP0 A;  4PK6 A;  4B6X A;  4CI1 B;  5LMN T;  3CQG B;  4LML A;  4WZX A;  1S35 A;  4TWF A;  4YTN A;  2NP9 A;  3NKZ A;  2CXD A;  4COF A;  4H9S E;  3SS1 A;  4AKL A;  5KXJ A;  1B7T A;  1S94 A;  3RIF A;  1KNP A;  1M7K A;  2V8S V;  2I59 A;  1HX8 A;  3AVS A;  1MIV A;  1SA0 E;  4NXN T;  4HGA A;  3NZP A;  3OPC A;  3JCF A;  3VRB A;  1XNR T;  4TWD A;  3PUV F;  3A7M A;  3AAA B;  4OHF A;  4JI3 T;  2WSS V;  3UU8 A;  1D0Y A;  4CN6 A;  4UIG A;  4ZI7 E;  2XSB A;  1D1A A;  2ZM0 A;  2KLQ A;  4PJM A;  1U4Q A;  2W67 A;  4O2B E;  2M6I A;  1KNZ A;  1OWA A;  2SPC A;  3FHN A;  2QYW A;  4L0R A;  1FIO A;  2UXC T;  4DR2 T;  3O4X E;  1UX4 A;  4PK4 A;  2XQ7 A;  3VKH A;  2JPF A;  1W0B A;  5L3G B;  3UT5 E;  5BMV E;  5AQF B;  1W0A A;  2VKH A;  4DV6 T;  3I0O A;  2HH7 A;  4AKH A;  1WYC A;  1HNW T;  4OX9 T;  2VL8 A;  3SRZ A;  2WU5 A;  5JDQ A;  5HEU A;  1CUN A;  2DL1 A;  1J5W A;  1N34 T;  3BK9 A;  2E9X C;  3ZT5 A;  1HS7 A;  5AQT B;  3EDV A;  2UUB T;  4EGW A;  3ZC0 A;  2D5U A;  4AIS A;  5LJN A;  4P09 A;  4Z8X A;  2D2S A;  4U31 A;  2VUR A;  4IRE A;  2JQH A;  2IW5 B;  5LMU T;  3GWH A;  4HFD A;  4P0B A;  4ADZ A;  2LSJ A;  3QOF A;  4HE8 A;  3ZEF B;  4JLE A;  4TN7 B;  2ZMA A;  2XJ7 A;  2NTX A;  2V7L A;  3M65 A;  3OBV E;  1EZ3 A;  2LKG A;  5AQO B;  4X5T A;  2AXD S;  4KP3 C;  3B57 A;  3GN5 A;  3NRY A;  2VB6 A;  3ANW B;  4WBO A;  2CM0 A;  2W00 A;  2BBJ A;  4JBW F;  2NWB A;  3C51 A;  4FJO A;  2XAJ B;  2HN2 A;  2DI4 A;  3FZM B;  2C0S A;  1VRB A;  5L2L A;  2E2A A;  5DQV A;  2IIU A;  2X0L B;  5J0Z A;  5L3F B;  2YU1 A;  2UXD T;  4BAY B;  3FBL A;  2V6Y A;  4WYV A;  2WMN A;  3PU3 A;  4MBQ A;  3P7I A;  4J2C A;  3K1S A;  1CHU A;  1VCT A;  3OKQ A;  5L4E A;  4YSZ A;  1NWM X;  2UXX B;  3KVA A;  1I6Z A;  1HG2 A;  2I0M A;  4EAH A;  5KDM C;  5J1G A;  4BJM A;  4GK0 E;  1ZOY A;  2NW7 A;  4H63 H;  2XHE B;  5ABH A;  2FBW A;  3Q9D A;  5LYJ E;  3M3Z B;  4YJ2 E;  2PBI A;  4ANJ A;  3AE2 A;  4DV2 T;  4PAG A;  4L9I A;  2BS4 A;  1FMW A;  3KIN B;  4ILC A;  3FBZ A;  5FY1 A;  3RC3 A;  3PUS A;  5DAB A;  4I0U A;  2BBH A;  3RHW A;  3UFG A;  5JDN A;  4IL9 A;  4KHZ F;  3AE1 A;  3CX6 B;  2FJA A;  3CPZ A;  1YQ4 A;  4ISS A;  2KZ7 B;  1JNR A;  5LB7 B;  2A9U A;  2C5J A;  2K48 A;  5JRC B;  3EHZ A;  1NAF A;  5HXH A;  3PU8 A;  2V7M A;  3HKD E;  4GYS A;  2E9X B;  4EZH A;  4JI2 T;  1IBM T;  2XQ4 A;  3CIR A;  4DO0 A;  1WYB A;  5KMG P;  4ZI2 C;  3AAI A;  3MZK B;  4IE6 A;  1YXR A;  4B3T T;  5FXX A;  2FJD A;  1IZN B;  4DBQ A;  2VQF T;  3AXJ A;  3C50 A;  2LT3 A;  2M6B A;  5CA0 E;  2J1D G;  3ABV A;  2BKP A;  2DWK A;  4PK5 A;  3RYC E;  3UU5 A;  3T1Y T;  2WM9 A;  4QH4 A;  4C90 A;  2CXF A;  2WCA A;  4JEH B;  3UQ4 A;  5FP3 A;  3FXD B;  2H3R A;  1FEW A;  5LXT E;  2A72 A;  4YJ3 E;  2LHN A;  5LNK A;  3QUJ A;  4DV1 T;  3LG7 A;  5AQM B;  2K3W A;  2CMR A;  3PJA J;  4YXD A;  2IUB A;  2ACZ A;  3B13 A;  1BR4 A;  2NTY A;  3FB2 A;  4DR1 T;  2X9H A;  3I9Y A;  4HWD A;  4DND A;  5AQL B;  4BJN A;  3K8P C;  2XAQ B;  1QLB A;  5JR9 C;  4NUV A;  2BKN A;  2C5I T;  2VL0 A;  4HFH A;  2IML A;  5ETW A;  4PJL A;  3FZK B;  3AA7 B;  4V1A v;  1UUS A;  3UUL A;  4O4L E;  3N9L A;  4E7S A;  3EAM A;  2YOE A;  3AED A;  5FXV A;  2ZM2 A;  2BZB A;  2CCQ A;  2IAK A;  2FJB A;  2H88 A;  3WI3 A;  1OED E;  2E8I A;  2XPK A;  3RKG A;  4KMC A;  3HL6 A;  4I43 B;  5LG4 A;  5HCJ A;  3Q5D A;  4IE5 A;  3UUX B;  1O3X A;  2LSK A;  1OED A;  5HXS A;  4ZXL A;  5HXC A;  1MNE A;  4ILA A;  2BVL A;  1XZY A;  1MIY A;  1ZKE A;  2YK0 A;  4DUY T;  3K3Q C;  4HKA A;  5LCY A;  4CN4 A;  5KX5 E;  2KIN B;  3P4P A;  2XZE A;  3ZYM A;  1HNZ T;  4PFO A;  4NPP A;  2QRX A;  4BA9 A;  2B1E A;  3UFE A;  5L47 A;  4AQF C;  5AQK B;  4EEB A;  3JAE A;  5L3E B;  3GA8 A;  4MHC A;  2Q9Q C;  1HR0 T;  5AQU B;  2WBL A;  4EYU A;  3KVB A;  2N9D A;  3J7Y q;  3MA9 A;  4DBR A;  3I0Q A;  2VK9 A;  4EV6 A;  3KDS E;  2MPK A;  2B76 A;  2WY2 A;  3LJC A;  3HA4 A;  4A5X A;  2KMF A;  3VR8 A;  1LVK A;  3N5L A;  1YKH B;  3K3N A;  4IL4 A;  4ZI3 D;  3ZMV B;  2BS2 A;  2L3L A;  2CXL A;  2D0T A;  2CWO A;  2WMO A;  3RRC A;  4TZ4 C;  3AEB A;  2XY8 B;  4U7Y A;  2BS3 A;  5BR8 T;  5HEO A;  5L3D B;  4JV5 T;  3V5S A;  4OK0 A;  1T72 A;  3U3I A;  3OYX A;  4ZEY A;  3UQ7 A;  5FNV E;  5HWY A;  3N2G E;  5IHY A;  4ZOL E;  3O1I A;  4DR5 T;  4GKK T;  4PFP A;  4NXM T;  2CEA A;  4JI1 T;  1U5P A;  1WCR A;  4IE4 A;  1UUR A;  5JR9 B;  2V5C A;  2BVM A;  2EHO C;  2VKD A;  2CRB A;  3RGL A;  4CI2 B;  1HCI A;  3AVR A;  3TLV A;  3S4U A;  2XQ9 A;  2LKH A;  2WWV A;  1ZEE A;  3MKD A;  3BQL A;  2YEV C;  1SHZ C;  4KI0 F;  2WS3 A;  2WAU A;  5ABF A;  3MAC A;  5JDG A;  3QB5 K;  3P4S A;  4UVC B;  3SFD A;  1FJG T;  4LF5 T;  1E1H B;  3E0Z A;  3JC6 C;  3RIU C;  3UU3 A;  3ZT7 A;  3PTR B;  4XBF B;  4UEM A;  2PJQ A;  1IJ5 A;  3TLW A;  3E08 A;  5AQN B;  3VRA A;  5HXR A;  4OYJ A;  2MAW A;  2MYS A;  3HKE E;  3PE0 A;  4EB6 E;  1MMA A;  3RKO A;  1W09 A;  4UV8 B;  1E2A A;  4E7Z A;  4AKG A;  4AI6 A;  2LE8 A;  3LBX A;  2X67 A;  2OA5 A;  2XQY A;  4ZHQ E;  2W61 A;  4HWI B;  5M4Y A;  2CBI A;  3VKG A;  2V7I A;  4IHJ E;  4NIQ A;  1YKE B;  3DTO A;  2Q9Q B;  4WBN E;  2N1G A;  2XQA A;  4QXH B;  5HWX A;  1WRD A;  4QKN A;  2XAF B;  2JQ9 A;  2X66 A;  3C4Z A;  3P4W A;  4DV3 T;  4LF9 T;  2M67 A;  4DR3 T;  3ZPO A;  3LSV A;  4EED A;  4NUU A;  5F3J A;  4HFB A;  3KV6 A;  4YT0 A;  3NZQ A;  5JDL A;  4Z91 A;  3B5M A;  2ZLY A;  2D9D A;  4MLK A;  3V5U A;  3UUM A;  3HI2 A;  3IA3 A;  3H37 A;  4F6R C;  4O2A E;  2PFV A;  4IGU A;  3F2E A;  4DR4 T;  2VQE T;  3OYZ A;  4K0K T;  3ONJ A;  3HKB E;  3TKL B;  4Z90 A;  3RQU A;  4UF0 A;  4CI3 B;  4LF8 T;  4DV4 T;  5JQG E;  2BKO A;  2DLR A;  5J2T E;  4JI0 T;  3WAJ A;  3G06 A;  1QUU A; 
#chains in the Genus database with same CATH homology
 5AQI B;  5AQO B;  3FZL B;  4HWF A;  4HWH A;  5AQN B;  5AQG B;  5AQM B;  5AQT B;  2D9D A;  4HWI B;  1UK5 A;  3M3Z B;  5AQV B;  3FZK B;  3FZF B;  5AQS B;  5AQF B;  3A8Y C;  1M62 A;  5AQK B;  1HX1 B;  1I6Z A;  5AQQ B;  1T7S A;  4HWC A;  5AQJ B;  3FZH B;  3LDQ B;  1UGO A;  5AQH B;  1M7K A;  4HWD A;  5AQR B;  5AQU B;  3FZM B;  5AQL B;  5AQP B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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