The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
75
|
sequence length |
266
|
structure length |
256
|
Chain Sequence |
HDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLIAKFPIKWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQCWNKSPEERPTFAETLHALETMF
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| molecule tags |
Transferase
|
| source organism |
Synthetic construct
|
| publication title |
Kinase Dynamics. Using Ancient Protein Kinases to Unravel a Modern Cancer Drug'S Mechanism.
pubmed doi rcsb |
| molecule keywords |
TYROSINE KINASE AS - A COMMON ANCESTOR OF SRC AND ABL
|
| total genus |
75
|
| structure length |
256
|
| sequence length |
266
|
| ec nomenclature |
ec
2.7.10.2: Non-specific protein-tyrosine kinase. |
| pdb deposition date | 2014-12-18 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Transferase(Phosphotransferase); domain 1 | Transferase(Phosphotransferase) domain 1 | ||
| Alpha Beta | 2-Layer Sandwich | Phosphorylase Kinase; domain 1 | Phosphorylase Kinase; domain 1 |
