The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
158
|
sequence length |
480
|
structure length |
467
|
Chain Sequence |
HYGITSPISLAAPKETDLLTQKLVETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLP
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
publication title |
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
pubmed doi rcsb |
molecule tags |
Transferase
|
source organism |
Bos taurus
|
molecule keywords |
Poly(A) polymerase alpha
|
total genus |
158
|
structure length |
467
|
sequence length |
480
|
ec nomenclature |
ec
2.7.7.19: Polynucleotide adenylyltransferase. |
pdb deposition date | 2003-08-16 |
chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
---|---|---|---|
A | PF01909 | NTP_transf_2 | Nucleotidyltransferase domain |
A | PF04926 | PAP_RNA-bind | Poly(A) polymerase predicted RNA binding domain |
A | PF04928 | PAP_central | Poly(A) polymerase central domain |
cath code
| Class | Architecture | Topology | Homology | Domain |
---|---|---|---|---|---|
Mainly Alpha | Orthogonal Bundle | Poly(a)-polymerase, middle domain | Poly(a)-polymerase, middle domain | ||
Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | Alpha-Beta Plaits | ||
Alpha Beta | 2-Layer Sandwich | Beta Polymerase; domain 2 | Beta Polymerase, domain 2 |