The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
108
|
sequence length |
313
|
structure length |
313
|
Chain Sequence |
SMSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFRGKVRTL
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.
pubmed rcsb |
| molecule tags |
Oxidoreductase/oxidoreductase inhibitor
|
| source organism |
Leishmania major
|
| molecule keywords |
Dihydroorotate dehydrogenase
|
| total genus |
108
|
| structure length |
313
|
| sequence length |
313
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
1.3.3.1: Transferred entry: 1.3.98.1. |
| pdb deposition date | 2012-03-29 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01180 | DHO_dh | Dihydroorotate dehydrogenase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Roll | Dihydroorotate Dehydrogenase A; chain A, domain 2 | Dihydroorotate Dehydrogenase A, chain A, domain 2 | ||
| Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I |
