The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
342
|
sequence length |
889
|
structure length |
889
|
Chain Sequence |
PKIHYRKDYKPSGFIINQVTLNINIHDQETIVRSVLDMDISKHNVGEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPETNYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKVNEFEIPGGRHGARFNDPPLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVSKLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKKNSIDFSYARILTVVGHEYFHQYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTRLSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYKKGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNYDAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFVFNNIAVKPIPSLFRGFSAPVYIEDQLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNYNEFLKAKNEKLESFQLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNLDTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNTLLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLLQEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKLIAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPQISNNLKEYLLRLTNK
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| molecule keywords |
M1 family aminopeptidase
|
| publication title |
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
pubmed doi rcsb |
| source organism |
Plasmodium falciparum
|
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| total genus |
342
|
| structure length |
889
|
| sequence length |
889
|
| ec nomenclature |
ec
3.4.11.-: |
| pdb deposition date | 2015-05-20 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01433 | Peptidase_M1 | Peptidase family M1 domain |
| A | PF11940 | DUF3458 | Domain of unknown function (DUF3458) Ig-like fold |
| A | PF17432 | DUF3458_C | Domain of unknown function (DUF3458_C) ARM repeats |
| A | PF17900 | Peptidase_M1_N | Peptidase M1 N-terminal domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Neutral Protease; domain 2 | Neutral Protease Domain 2 | ||
| Mainly Alpha | Orthogonal Bundle | Rna Polymerase Sigma Factor; Chain: A | Rna Polymerase Sigma Factor; Chain: A | ||
| Mainly Alpha | Alpha Horseshoe | Zincin-like fold | Peptidase M1, alanyl aminopeptidase, C-terminal domain | ||
| Mainly Beta | Sandwich | Immunoglobulin-like | tricorn interacting facor f3 domain | ||
| Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulin-like |
