The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
187
|
sequence length |
577
|
structure length |
577
|
Chain Sequence |
b'QAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVGDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAD'
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.
pubmed doi rcsb |
| molecule keywords |
Methionine synthase
|
| source organism |
Escherichia coli
|
| molecule tags |
Transferase
|
| total genus |
187
|
| structure length |
577
|
| sequence length |
577
|
| ec nomenclature |
ec
2.1.1.13: Methionine synthase. |
| pdb deposition date | 2001-10-27 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF02310 | B12-binding | B12 binding domain |
| A | PF02607 | B12-binding_2 | B12 binding domain |
| A | PF02965 | Met_synt_B12 | Vitamin B12 dependent methionine synthase, activation domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Cobalamin-dependent Methionine Synthase; domain 2 | Cobalamin-dependent Methionine Synthase, domain 2 | ||
| Mainly Alpha | Orthogonal Bundle | Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 | Methionine synthase domain | ||
| Alpha Beta | Roll | Cobalamin-dependent Methionine Synthase; domain 1 | Vitamin B12-dependent methionine synthase, activation domain | ||
| Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Cobalamin-binding domain |
